efhc1 EF-hand domain (C-terminal) containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: efhc1provided by ZNC
Official Full Name: EF-hand domain (C-terminal) containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1300
See related: Ensembl:ENSDARG00000009743 AllianceGenome:ZFIN:ZDB-GENE-040426-1300
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63931
Summary: Predicted to enable alpha-tubulin binding activity. Predicted to be involved in cilium-dependent cell motility; mitotic cytokinesis; and mitotic spindle organization. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in axoneme and mitotic spindle. Is expressed in several structures, including Kupffer's vesicle; central nervous system; forerunner cell group; neural tube; and pronephros. Human ortholog(s) of this gene implicated in juvenile absence epilepsy 1 and juvenile myoclonic epilepsy. Orthologous to human EFHC1 (EF-hand domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (48141998..48157595, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (47664692..47680289, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium-dependent cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EF-hand domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200967.1 → NP_957261.1 EF-hand domain-containing protein 1

See identical proteins and their annotated locations for NP_957261.1

Status: PROVISIONAL

Source sequence(s)

BC054573

UniProtKB/TrEMBL

Q7T2F1

Related

ENSDARP00000007503.6, ENSDART00000023058.8

Conserved Domains (2) summary

smart00676
Location:93 → 198

DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases

pfam06565
Location:121 → 153

DUF1126; Repeat of unknown function (DUF1126)