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    NPR3 NPR1-like protein 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834545, updated on 7-Sep-2023

    Summary

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    Gene symbol
    NPR3
    Gene description
    NPR1-like protein 3
    Primary source
    Araport:AT5G45110
    Locus tag
    AT5G45110
    See related
    TAIR:AT5G45110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNPR3; K17O22.11; K17O22_11; NPR1-like protein 3
    Summary
    Encodes NPR3, a paralog of NPR1. Involved in negative regulation of defense responses against bacterial and oomycete pathogens. npr3 mutants has elevated level of PR1 expression. Interacts with TGA2, TGA3, TGA5 and TGA6 in yeast two hybrid assays. NPR3 and NPR4 are receptors for the immune signal salicylic acid.
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    Genomic context

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    See NPR3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (18228768..18231588)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene SBP (S-ribonuclease binding protein) family protein Neighboring gene miscRNA Neighboring gene mitochondrial transcription termination factor-related / mTERF-like protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway. Rong D, et al. Mol Plant, 2016 Nov 7. PMID 27575693, Free PMC Article
    2. Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity. Ding Y, et al. Cell, 2018 May 31. PMID 29656896
    3. The salicylic acid receptor NPR3 is a negative regulator of the transcriptional defense response during early flower development in Arabidopsis. Shi Z, et al. Mol Plant, 2013 May. PMID 22986789
    4. NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. Fu ZQ, et al. Nature, 2012 May 16. PMID 22699612, Free PMC Article
    5. Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs. Zhang Y, et al. Plant J, 2006 Dec. PMID 17076807

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both NPR1 and NPR3/NPR4 are bona fide salicylic acid receptors, but play opposite roles in transcriptional regulation of salicylic acid-induced defense gene expression
      Title: Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity.
    2. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway
      Title: Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway.
    3. NPR3 expression was strongest in the petals and sepals of developing flowers and declined after flower opening.
      Title: The salicylic acid receptor NPR3 is a negative regulator of the transcriptional defense response during early flower development in Arabidopsis.
    4. the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind salicylic acid with different affinities
      Title: NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
    5. NPR3 and NPR4 negatively regulate PR gene expression and pathogen resistance through their association with TGA2 and its paralogs.[NPR3]
      Title: Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344586.1
    NM_123879.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables salicylic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of jasmonic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of salicylic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within systemic acquired resistance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in systemic acquired resistance, salicylic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NPR1-like protein 3
    NP_199324.2
    • NPR1-like protein 3 (NPR3); INVOLVED IN: defense response to fungus, incompatible interaction, defense response to bacterium, incompatible interaction; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), NPR1/NIM1 like, C-terminal (InterPro:IPR021094), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: NPR1-like protein 4 (TAIR:AT4G19660.1); Has 2270 Blast hits to 1933 proteins in 191 species: Archae - 0; Bacteria - 121; Metazoa - 545; Fungi - 58; Plants - 638; Viruses - 9; Other Eukaryotes - 899 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18228768..18231588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123879.3 → NP_199324.2  NPR1-like protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199324.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L746, Q9FHE3
      UniProtKB/TrEMBL
      A0A178UGU4, A0A5S9YBC2, A0A7G2FKH6
      Conserved Domains (5) summary
      sd00045
      Location:295 → 322
      ANK; ANK repeat [structural motif]
      pfam11900
      Location:220 → 267
      DUF3420; Domain of unknown function (DUF3420)
      cd18310
      Location:42 → 185
      BTB_POZ_NPR_plant; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins
      pfam12313
      Location:366 → 561
      NPR1_like_C; NPR1/NIM1 like defense protein C terminal
      pfam12796
      Location:269 → 350
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001344586.1 → NP_001330386.1  NPR1-like protein 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BAP1, A0A7G2FKH6
      Conserved Domains (5) summary
      sd00045
      Location:295 → 322
      ANK; ANK repeat [structural motif]
      pfam11900
      Location:220 → 267
      DUF3420; Domain of unknown function (DUF3420)
      cd18310
      Location:42 → 185
      BTB_POZ_NPR_plant; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins
      pfam12313
      Location:366 → 495
      NPR1_like_C; NPR1/NIM1 like defense protein C terminal
      pfam12796
      Location:269 → 350
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L746.1

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