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    Nlrx1 NLR family member X1 [ Mus musculus (house mouse) ]

    Gene ID: 270151, updated on 13-May-2024

    Summary

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    Official Symbol
    Nlrx1provided by MGI
    Official Full Name
    NLR family member X1provided by MGI
    Primary source
    MGI:MGI:2429611
    See related
    Ensembl:ENSMUSG00000032109 AllianceGenome:MGI:2429611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NOD9
    Summary
    Predicted to enable ATP binding activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of cytokine production; and negative regulation of defense response. Located in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 11.8), adrenal adult (RPKM 10.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nlrx1 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44164010..44179896, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44252713..44268599, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 153 Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene histone H4 transcription factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mechanism of NLRX1 Mediating JNK Apoptosis Pathway to Participate in Functional Impairment of Cochlear Hair Cells in Mice with Senile Deafness. Yang X, et al. Cell Mol Biol (Noisy-le-grand), 2022 Sep 30. PMID 37114263
    2. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Kim HR, et al. Sci Rep, 2023 Mar 1. PMID 36859435, Free PMC Article
    3. Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1. Killackey SA, et al. Mol Cell, 2022 Aug 4. PMID 35752171
    4. Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor. Snäkä T, et al. Front Immunol, 2022. PMID 35651602, Free PMC Article
    5. Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes. Shin HJ, et al. Aging Cell, 2021 Jul. PMID 34087956, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
      Title: NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
    2. NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy.
      Title: NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy.
    3. Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1.
      Title: Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1.
    4. Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
      Title: Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
    5. Mechanism of NLRX1 Mediating JNK Apoptosis Pathway to Participate in Functional Impairment of Cochlear Hair Cells in Mice with Senile Deafness.
      Title: Mechanism of NLRX1 Mediating JNK Apoptosis Pathway to Participate in Functional Impairment of Cochlear Hair Cells in Mice with Senile Deafness.
    6. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.
      Title: NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.
    7. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
      Title: Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
    8. NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-kappaB and NLRP3 inflammasome.
      Title: NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-κB and NLRP3 inflammasome.
    9. HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
      Title: HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
    10. NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
      Title: NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Nherf4

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NLR family member X1
    Names
    nucleotide-binding domain and leucine-rich repeat containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163742.1 → NP_001157214.1  NLR family member X1

      See identical proteins and their annotated locations for NP_001157214.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK166689, BC035045, BY196718
      Consensus CDS
      CCDS23100.1
      UniProtKB/Swiss-Prot
      Q3TL44, Q3UKJ1, Q80W30, Q8C249
      Related
      ENSMUSP00000127531.2, ENSMUST00000168499.9
      Conserved Domains (3) summary
      cd00116
      Location:698 → 903
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001163743.1 → NP_001157215.1  NLR family member X1

      See identical proteins and their annotated locations for NP_001157215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124577, BC035045
      Consensus CDS
      CCDS23100.1
      UniProtKB/Swiss-Prot
      Q3TL44, Q3UKJ1, Q80W30, Q8C249
      Related
      ENSMUSP00000126555.2, ENSMUST00000169651.3
      Conserved Domains (3) summary
      cd00116
      Location:698 → 903
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_178420.3 → NP_848507.2  NLR family member X1

      See identical proteins and their annotated locations for NP_848507.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124577, AK145988, BC035045
      Consensus CDS
      CCDS23100.1
      UniProtKB/Swiss-Prot
      Q3TL44, Q3UKJ1, Q80W30, Q8C249
      Related
      ENSMUSP00000034621.9, ENSMUST00000034621.16
      Conserved Domains (3) summary
      cd00116
      Location:698 → 903
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44164010..44179896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TL44.1 GenPept UniProtKB/Swiss-Prot:Q3TL44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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