Clec2g C-type lectin domain family 2, member g [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec2gprovided by MGI
Official Full Name: C-type lectin domain family 2, member gprovided by MGI
Primary source: MGI:MGI:1918059
See related: Ensembl:ENSMUSG00000000248 AllianceGenome:MGI:1918059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clrc; Clrd; Clrx; Clr-c; Clr-d; Ddv10; Ocilrp1; 4632413B12Rik
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.11 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128911344..128961670)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128934381..128984707)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice.
Title: Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice.
CLEC-2 is an adhesive receptor that supports platelet arrest to podoplanin under venous shear. Src/Syk-dependent signalling stabilises platelet adhesion to podoplanin.
Title: Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.
Both circulating B lymphocytes and CD11b-high Gr-1-high myeloid cells lose CLEC-2 following entry into secondary lymphoid organs.
Title: The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state.
aggretin may induce cytokine TNF-alpha/IL-6 release via interacting with CLEC-2 receptor and the subsequent MAPK and NF-kappaB activation in monocytes/macrophages
Title: A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation.
Data suggest that DDV10 is the long form of Clec2 g (Clec2g-L), and DDV10/Clec2g-L may play a role in the stratification and/or cornification of epithelial cells during differentiation.
Title: Tissue-specific expression of Clec2g in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables natural killer cell lectin-like receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables natural killer cell lectin-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type lectin domain family 2 member G

Names: C-type lectin-related protein C; ocil-related protein 1; osteoclast inhibitory lectin related protein; osteoclast inhibitory lectin-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168223.1 → NP_001161695.1 C-type lectin domain family 2 member G isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK014570, AK137753, AY137342

Consensus CDS

CCDS85167.1

UniProtKB/TrEMBL

A0A0N4SUR3, G3EZR8

Related

ENSMUSP00000144788.2, ENSMUST00000203405.3

Conserved Domains (1) summary

cd03593
Location:86 → 198

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001168224.1 → NP_001161696.1 C-type lectin domain family 2 member G isoform 3

See identical proteins and their annotated locations for NP_001161696.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK014570, AK137753, AY137341

Consensus CDS

CCDS51921.1

UniProtKB/TrEMBL

F5CSM6, G3EZR8

Related

ENSMUSP00000115140.2, ENSMUST00000142388.8

Conserved Domains (1) summary

cd03593
Location:81 → 193

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001316752.1 → NP_001303681.1 C-type lectin domain family 2 member G isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC159305, AY137341, JF792239

Consensus CDS

CCDS85168.1

UniProtKB/TrEMBL

F5CSM7, G3EZR8

Related

ENSMUSP00000144879.2, ENSMUST00000204259.3

Conserved Domains (1) summary

cd03593
Location:92 → 204

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_027562.4 → NP_081838.1 C-type lectin domain family 2 member G isoform 1

See identical proteins and their annotated locations for NP_081838.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK014570, AK137753

Consensus CDS

CCDS20578.1

UniProtKB/Swiss-Prot

Q1AFZ6, Q3UUY2, Q80Z35, Q8BHH6, Q9D676

Related

ENSMUSP00000000254.8, ENSMUST00000000254.14

Conserved Domains (2) summary

cd03593
Location:143 → 255

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

cl02432
Location:23 → 59

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain