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    Ankrd60 ankyrin repeat domain 60 [ Mus musculus (house mouse) ]

    Gene ID: 70065, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd60provided by MGI
    Official Full Name
    ankyrin repeat domain 60provided by MGI
    Primary source
    MGI:MGI:1917315
    See related
    Ensembl:ENSMUSG00000027517 AllianceGenome:MGI:1917315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700019A24Rik; 1700030G11Rik
    Summary
    Orthologous to human ANKRD60 (ankyrin repeat domain 60). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 162.4) See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd60 in Genome Data Viewer
    Location:
    2 H4; 2 97.04 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173410451..173420066, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173568658..173578273, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 1 Neighboring gene predicted gene, 54093 Neighboring gene protein phosphatase 4, regulatory subunit 1-like, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8799 Neighboring gene STARR-positive B cell enhancer ABC_E7891 Neighboring gene RAB22A, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E648 Neighboring gene microRNA 6340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Folding landscapes of ankyrin repeat proteins: experiments meet theory. Barrick D, et al. Curr Opin Struct Biol, 2008 Feb. PMID 18243686, Free PMC Article
    2. The ankyrin repeat: a diversity of interactions on a common structural framework. Sedgwick SG, et al. Trends Biochem Sci, 1999 Aug. PMID 10431175
    3. The ankyrin repeat as molecular architecture for protein recognition. Mosavi LK, et al. Protein Sci, 2004 Jun. PMID 15152081, Free PMC Article
    4. Ankyrin repeat: a unique motif mediating protein-protein interactions. Li J, et al. Biochemistry, 2006 Dec 26. PMID 17176038
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199955.2 → NP_001186884.2  ankyrin repeat domain-containing protein 60 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL807384
      Related
      ENSMUST00000147693.2
      Conserved Domains (1) summary
      cl28922
      Location:1 → 53
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_027303.2 → NP_081579.2  ankyrin repeat domain-containing protein 60 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL807384
      Consensus CDS
      CCDS50815.1
      UniProtKB/TrEMBL
      A0A6I8MWY2, A6PWV4
      Related
      ENSMUSP00000159317.2, ENSMUST00000239457.2
      Conserved Domains (4) summary
      PHA02875
      Location:59 → 219
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:108 → 135
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:109 → 187
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:1 → 53
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173410451..173420066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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