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    Fxyd4 FXYD domain-containing ion transport regulator 4 [ Mus musculus (house mouse) ]

    Gene ID: 108017, updated on 4-May-2024

    Summary

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    Official Symbol
    Fxyd4provided by MGI
    Official Full Name
    FXYD domain-containing ion transport regulator 4provided by MGI
    Primary source
    MGI:MGI:1889005
    See related
    Ensembl:ENSMUSG00000004988 AllianceGenome:MGI:1889005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chif; 0610008I02Rik
    Summary
    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in kidney adult (RPKM 19.0), ovary adult (RPKM 6.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fxyd4 in Genome Data Viewer
    Location:
    6 F1; 6 55.7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117910519..117914668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117933558..117937714, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17123 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850148-117850426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850781-117850973 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1069 Neighboring gene STARR-seq mESC enhancer starr_17127 Neighboring gene heterogeneous nuclear ribonucleoprotein F Neighboring gene STARR-seq mESC enhancer starr_17129 Neighboring gene STARR-seq mESC enhancer starr_17131 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene RasGEF domain family, member 1A Neighboring gene STARR-seq mESC enhancer starr_17132 Neighboring gene STARR-seq mESC enhancer starr_17134 Neighboring gene microRNA 7044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kidney and colon electrolyte transport in CHIF knockout mice. Goldschmidt I, et al. Cell Physiol Biochem, 2004. PMID 14976412
    2. Generation and phenotypic analysis of CHIF knockout mice. Aizman R, et al. Am J Physiol Renal Physiol, 2002 Sep. PMID 12167609
    3. FXYD3 (Mat-8), a new regulator of Na,K-ATPase. Crambert G, et al. Mol Biol Cell, 2005 May. PMID 15743908, Free PMC Article
    4. FXYD proteins: new regulators of Na-K-ATPase. Geering K. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403837
    5. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, et al. Genomics, 2000 Aug 15. PMID 10950925

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107631

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FXYD domain-containing ion transport regulator 4
    Names
    channel inducing factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173372.1 → NP_001166843.1  FXYD domain-containing ion transport regulator 4 precursor

      See identical proteins and their annotated locations for NP_001166843.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018728, AU041511
      Consensus CDS
      CCDS20468.1
      UniProtKB/Swiss-Prot
      Q9D2W0
      UniProtKB/TrEMBL
      A0A0N4SVN7
      Related
      ENSMUSP00000145302.2, ENSMUST00000204214.3
      Conserved Domains (1) summary
      pfam02038
      Location:25 → 70
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. NM_033648.1 → NP_387468.1  FXYD domain-containing ion transport regulator 4 precursor

      See identical proteins and their annotated locations for NP_387468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018728, BC086918
      Consensus CDS
      CCDS20468.1
      UniProtKB/Swiss-Prot
      Q9D2W0
      UniProtKB/TrEMBL
      A0A0N4SVN7
      Related
      ENSMUSP00000005114.8, ENSMUST00000005114.10
      Conserved Domains (1) summary
      pfam02038
      Location:25 → 70
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      117910519..117914668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505295.5 → XP_006505358.1  FXYD domain-containing ion transport regulator 4 isoform X2

      See identical proteins and their annotated locations for XP_006505358.1

      UniProtKB/Swiss-Prot
      Q9D2W0
      UniProtKB/TrEMBL
      A0A0N4SVN7
      Related
      ENSMUSP00000144700.2, ENSMUST00000203082.3
      Conserved Domains (1) summary
      pfam02038
      Location:25 → 70
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. XM_017321297.3 → XP_017176786.1  FXYD domain-containing ion transport regulator 4 isoform X1

      Conserved Domains (1) summary
      pfam02038
      Location:89 → 134
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2W0.1 GenPept UniProtKB/Swiss-Prot:Q9D2W0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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