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    Fam135a family with sequence similarity 135, member A [ Mus musculus (house mouse) ]

    Gene ID: 68187, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Fam135aprovided by MGI
    Official Full Name
    family with sequence similarity 135, member Aprovided by MGI
    Primary source
    MGI:MGI:1915437
    See related
    Ensembl:ENSMUSG00000026153 AllianceGenome:MGI:1915437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921533L14Rik
    Summary
    Predicted to be involved in cellular lipid metabolic process. Is expressed in neural retinal epithelium; peripheral nervous system; retina layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human FAM135A (family with sequence similarity 135 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 7.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam135a in Genome Data Viewer
    Location:
    1 A5; 1 9.87 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (24049824..24139444, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (24010758..24100484, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene small ArfGAP 1 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene STARR-seq mESC enhancer starr_00445 Neighboring gene predicted gene, 30756 Neighboring gene STARR-seq mESC enhancer starr_00447 Neighboring gene collagen, type IX, alpha 1 Neighboring gene collagen, type XIX, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_00448 Neighboring gene STARR-seq mESC enhancer starr_00450 Neighboring gene STARR-seq mESC enhancer starr_00451 Neighboring gene predicted gene, 26418

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1411

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM135A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403087.1 → NP_001390016.1  protein FAM135A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    2. NM_001403088.1 → NP_001390017.1  protein FAM135A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    3. NM_001403089.1 → NP_001390018.1  protein FAM135A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    4. NM_001403090.1 → NP_001390019.1  protein FAM135A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325
      UniProtKB/Swiss-Prot
      Q3UEW1, Q5XK31, Q6NS59, Q8BXS8, Q8BZL9, Q8K2K2, Q9D2J6
      Conserved Domains (2) summary
      pfam05057
      Location:1235 → 1430
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 172
      DUF3657; Protein FAM135

    5. NM_001403091.1 → NP_001390020.1  protein FAM135A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    6. NM_001403092.1 → NP_001390021.1  protein FAM135A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325
      Related
      ENSMUSP00000139633.2, ENSMUST00000187752.7

    7. NM_001403093.1 → NP_001390022.1  protein FAM135A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    8. NM_001403094.1 → NP_001390023.1  protein FAM135A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325
      UniProtKB/TrEMBL
      A0A087WRT5

    9. NM_001403095.1 → NP_001390024.1  protein FAM135A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325
      UniProtKB/TrEMBL
      A0A087WRT5
      Related
      ENSMUSP00000140766.2, ENSMUST00000187369.7

    10. NM_001403096.1 → NP_001390025.1  protein FAM135A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    11. NM_001403097.1 → NP_001390026.1  protein FAM135A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    12. NM_026604.4 → NP_080880.4  protein FAM135A isoform 3

      See identical proteins and their annotated locations for NP_080880.4

      Status: VALIDATED

      Source sequence(s)
      AK034175, AK044359, BC070446, BM200880, BY732479
      Consensus CDS
      CCDS14853.1
      UniProtKB/Swiss-Prot
      Q3UEW1, Q5XK31, Q6NS59, Q8BXS8, Q8BZL9, Q8K2K2, Q9D2J6
      UniProtKB/TrEMBL
      A0A087WP54
      Related
      ENSMUSP00000027337.9, ENSMUST00000027337.15
      Conserved Domains (2) summary
      pfam05057
      Location:1235 → 1430
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 172
      DUF3657; Protein FAM135

    RNA

    1. NR_175350.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123790, AC129325

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      24049824..24139444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238569.3 → XP_011236871.1  protein FAM135A isoform X14

      Conserved Domains (1) summary
      pfam05057
      Location:645 → 840
      DUF676; Putative serine esterase (DUF676)

    2. XM_030242598.2 → XP_030098458.1  protein FAM135A isoform X11

      Conserved Domains (1) summary
      pfam05057
      Location:841 → 1036
      DUF676; Putative serine esterase (DUF676)

    3. XM_006496232.5 → XP_006496295.1  protein FAM135A isoform X2

      UniProtKB/TrEMBL
      A0A087WP54
      Conserved Domains (2) summary
      pfam05057
      Location:1239 → 1434
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:115 → 175
      DUF3657; Protein FAM135

    4. XM_017322275.3 → XP_017177764.1  protein FAM135A isoform X6

      UniProtKB/TrEMBL
      A0A087WP54
      Conserved Domains (2) summary
      pfam05057
      Location:1043 → 1238
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:115 → 175
      DUF3657; Protein FAM135

    5. XM_030242599.2 → XP_030098459.1  protein FAM135A isoform X12

      Conserved Domains (1) summary
      pfam05057
      Location:810 → 1005
      DUF676; Putative serine esterase (DUF676)

    6. XM_036153271.1 → XP_036009164.1  protein FAM135A isoform X10

      Conserved Domains (1) summary
      pfam05057
      Location:861 → 1056
      DUF676; Putative serine esterase (DUF676)

    7. XM_030242596.2 → XP_030098456.1  protein FAM135A isoform X10

      Conserved Domains (1) summary
      pfam05057
      Location:861 → 1056
      DUF676; Putative serine esterase (DUF676)

    8. XM_030242600.2 → XP_030098460.1  protein FAM135A isoform X12

      Conserved Domains (1) summary
      pfam05057
      Location:810 → 1005
      DUF676; Putative serine esterase (DUF676)

    9. XM_030242597.1 → XP_030098457.1  protein FAM135A isoform X10

      Conserved Domains (1) summary
      pfam05057
      Location:861 → 1056
      DUF676; Putative serine esterase (DUF676)

    RNA

    1. XR_004934154.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NS59.2 GenPept UniProtKB/Swiss-Prot:Q6NS59

    Gene LinkOut

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