PCA3 prostate cancer associated 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PCA3provided by HGNC
Official Full Name: prostate cancer associated 3provided by HGNC
Primary source: HGNC:HGNC:8637
See related: Ensembl:ENSG00000225937 MIM:604845; AllianceGenome:HGNC:8637
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DD3; PCAT3; NCRNA00019; PRUNE2-AS1
Summary: This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Expression: Restricted expression toward prostate (RPKM 4.9) See more
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Genomic context

Location:: 9q21.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (76764436..76787569)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (88920862..88944017)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (79379352..79402485)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis.
Title: lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis.
Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men.
Title: Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men.
PCA3 controls chromatin organization and p53 signal activation by regulating LAP2alpha-lamin A complexes.
Title: PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes.
Circulating RNAs in prostate cancer patients.
Title: Circulating RNAs in prostate cancer patients.
LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
Title: LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
Promoter polymorphisms of the PCA3 gene are not associated with its overexpression in prostate cancer patients.
Title: Promoter polymorphisms of the PCA3 gene are not associated with its overexpression in prostate cancer patients.
These results show that the lncRNAs PCA3 and HAM-1 are upregulated during thyroid tumor development and progression and may function as oncogenes during tumor progression
Title: Long Non-coding RNA Expression in Anaplastic Thyroid Carcinomas.
Using information visualization methods, we could also distinguish between cell lines expressing the endogenous PCA3 long noncoding RNA (lncRNA) from cells that did not contain detectable levels of this biomarker.
Title: Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors.
PCA3 but not T2:ERG was associated with cancer reclassification in the first surveillance biopsy, but has negligible improvement over clinical variables alone in receiver operating characteristic curves or decision curve analyses. Neither marker was associated with reclassification in subsequent biopsies.
Title: Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS).
Urine prostate cancer gene 3 (PCA3) is significantly elevated in patients with prostate cancer and can be used for the diagnosis of prostate cancer, but its cutoff value is still controversial--{REVIEW}
Title: Comparison of diagnostic efficacy by two urine PCA3 scores in prostate cancer patients undergoing repeat biopsies.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Markers

RH121153 (e-PCR)
- UniSTS:134148

SHGC-82569 (e-PCR)
- UniSTS:95660

Other Names

Differential Display code 3
PRUNE2 antisense RNA 1
prostate cancer antigen 3 (non-protein coding)
prostate cancer associated 3 (non-protein coding)
prostate cancer associated transcript 3 (non-protein coding)
prostate-specific gene DD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_015342.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon compared to variant 1.

Source sequence(s)

AF103907, AY894120

Related

ENST00000645809.1
NR_132312.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AF103907, AY894120

Related

ENST00000412654.1
NR_132313.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice site, which results in a shorter transcript compared to variant 1.

Source sequence(s)

AF103907, AY894120, DQ374661