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    Morf4l1 mortality factor 4 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300891, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Morf4l1provided by RGD
    Official Full Name
    mortality factor 4 like 1provided by RGD
    Primary source
    RGD:1307938
    See related
    Ensembl:ENSRNOG00000058412 AllianceGenome:RGD:1307938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and protein N-terminus binding activity. Predicted to be involved in double-strand break repair via homologous recombination; heterochromatin assembly; and histone modification. Predicted to act upstream of or within cell population proliferation. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex and Sin3 complex. Orthologous to human MORF4L1 (mortality factor 4 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 327.0), Testes (RPKM 311.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Morf4l1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (99522801..99544432, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (90642988..90664518, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (97473454..97494974, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094225 Neighboring gene cathepsin H Neighboring gene transfer RNA lysine (anticodon CUU) 18 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MRG15 regulates embryonic development and cell proliferation. Tominaga K, et al. Mol Cell Biol, 2005 Apr. PMID 15798182, Free PMC Article
    2. PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. Tominaga K, et al. Mol Cell Biol, 2004 Oct. PMID 15367658, Free PMC Article
    3. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. Hayakawa T, et al. J Cell Sci, 2010 Apr 1. PMID 20332121, Free PMC Article
    4. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. Miele A, et al. J Cell Biochem, 2007 Sep 1. PMID 17577209
    5. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Sin3-type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Sin3-type complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mortality factor 4-like protein 1
    Names
    MORF-related gene 15 protein
    transcription factor-like protein MRG15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011999.2 → NP_001011999.1  mortality factor 4-like protein 1

      See identical proteins and their annotated locations for NP_001011999.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q6AYU1
      UniProtKB/TrEMBL
      A0A8I6ANZ2, A6I217
      Related
      ENSRNOP00000095145.1, ENSRNOT00000103722.1
      Conserved Domains (2) summary
      pfam05712
      Location:135 → 309
      MRG; MRG
      pfam11717
      Location:11 → 64
      Tudor-knot; RNA binding activity-knot of a chromodomain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      99522801..99544432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766445.4 → XP_008764667.1  mortality factor 4-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_008764667.1

      UniProtKB/TrEMBL
      A0A8I6A2P7, A0A8I6ANZ2, A6I218
      Related
      ENSRNOP00000086652.1
      Conserved Domains (2) summary
      pfam05712
      Location:174 → 348
      MRG; MRG
      pfam11717
      Location:11 → 103
      Tudor-knot; RNA binding activity-knot of a chromodomain

    2. XM_063265204.1 → XP_063121274.1  mortality factor 4-like protein 1 isoform X7

    3. XM_017595579.3 → XP_017451068.1  mortality factor 4-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ANZ2

    4. XM_063265203.1 → XP_063121273.1  mortality factor 4-like protein 1 isoform X6

    5. XM_063265202.1 → XP_063121272.1  mortality factor 4-like protein 1 isoform X5

    6. XM_063265201.1 → XP_063121271.1  mortality factor 4-like protein 1 isoform X2

    7. XM_063265200.1 → XP_063121270.1  mortality factor 4-like protein 1 isoform X1

    8. XM_063265205.1 → XP_063121275.1  mortality factor 4-like protein 1 isoform X8

    9. XM_063265206.1 → XP_063121276.1  mortality factor 4-like protein 1 isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYU1.1 GenPept UniProtKB/Swiss-Prot:Q6AYU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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