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    Rrp1b ribosomal RNA processing 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309673, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rrp1bprovided by RGD
    Official Full Name
    ribosomal RNA processing 1Bprovided by RGD
    Primary source
    RGD:1305633
    See related
    Ensembl:ENSRNOG00000001194 AllianceGenome:RGD:1305633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305633
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of GTPase activity; positive regulation by host of viral transcription; and regulation of RNA metabolic process. Predicted to be located in chromatin and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleus. Orthologous to human RRP1B (ribosomal RNA processing 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 43.3), Spleen (RPKM 40.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rrp1b in Genome Data Viewer
    Location:
    20p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10122825..10148404)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10123111..10148704)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10844234..10869830)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098852 Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene pyridoxal kinase like 1 Neighboring gene pyridoxal kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription. Su WC, et al. J Virol, 2015 Nov. PMID 26311876, Free PMC Article
    2. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. Crawford NP, et al. PLoS Genet, 2007 Nov. PMID 18081427, Free PMC Article
    3. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. Paik JC, et al. J Biol Chem, 2010 Feb 26. PMID 20040599, Free PMC Article
    4. RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1. Lee M, et al. Oncogene, 2014 Apr 3. PMID 23604122, Free PMC Article
    5. RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits. Chamousset D, et al. Mol Biol Cell, 2010 Dec. PMID 20926688, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in granular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal RNA processing protein 1 homolog B
    Names
    ribosomal RNA processing 1 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427282.1 → NP_001414211.1  ribosomal RNA processing protein 1 homolog B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10122825..10148404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601874.3 → XP_017457363.1  ribosomal RNA processing protein 1 homolog B isoform X1

      UniProtKB/TrEMBL
      D3ZY39
      Related
      ENSRNOP00000001583.7
      Conserved Domains (1) summary
      pfam05997
      Location:2 → 148
      Nop52; Nucleolar protein,Nop52
    Nucleotide Protein Strain
    Heading Accession and Version

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