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    Mical3 microtubule associated monooxygenase, calponin and LIM domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362427, updated on 25-Apr-2024

    Summary

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    Symbol
    Mical3provided by RGD
    Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 3provided by RGD
    Primary source
    RGD:1359504
    See related
    Ensembl:ENSRNOG00000053203 AllianceGenome:RGD:1359504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin filament depolymerization. Predicted to be located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. Orthologous to human MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 150.3), Uterus (RPKM 116.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mical3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155824941..156025003, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154152776..154353274, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153484876..153631986, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Bcl2-like 13 Neighboring gene BH3 interacting domain death agonist Neighboring gene uncharacterized LOC134486634 Neighboring gene uncharacterized LOC134486633 Neighboring gene uncharacterized LOC134486635 Neighboring gene peroxisomal biogenesis factor 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Pasterkamp RJ, et al. Mol Cell Neurosci, 2006 Jan. PMID 16230022
    2. The MICAL proteins and rab1: a possible link to the cytoskeleton? Fischer J, et al. Biochem Biophys Res Commun, 2005 Mar 11. PMID 15694364
    3. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Lundquist MR, et al. Cell, 2014 Jan 30. PMID 24440334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord.
      Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
    2. Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton.
      Title: The MICAL proteins and rab1: a possible link to the cytoskeleton?
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-actin-monooxygenase MICAL3
    Names
    flavoprotein oxidoreductase MICAL3
    microtubule associated monoxygenase, calponin and LIM domain containing 3
    protein MICAL-3
    protein-methionine sulfoxide oxidase MICAL3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191085.4 → NP_001178014.2  F-actin-monooxygenase MICAL3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AA21, D3ZGN7
      Conserved Domains (5) summary
      cd09439
      Location:764 → 818
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1114 → 1507
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:1849 → 1978
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    2. NM_001415882.2 → NP_001402811.1  F-actin-monooxygenase MICAL3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZGN7
      Related
      ENSRNOP00000072316.1, ENSRNOT00000082982.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155824941..156025003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107870.2 → XP_038963798.1  F-actin-monooxygenase MICAL3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2256
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    2. XM_039107872.2 → XP_038963800.1  F-actin-monooxygenase MICAL3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2256
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    3. XM_063286323.1 → XP_063142393.1  F-actin-monooxygenase MICAL3 isoform X14

    4. XM_039107884.2 → XP_038963812.1  F-actin-monooxygenase MICAL3 isoform X13

      UniProtKB/TrEMBL
      A0A8I5Y064
      Related
      ENSRNOP00000076562.1
      Conserved Domains (5) summary
      cd09439
      Location:764 → 818
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1165 → 1558
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:1917 → 2085
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    5. XM_039107882.2 → XP_038963810.1  F-actin-monooxygenase MICAL3 isoform X12

      UniProtKB/TrEMBL
      A0A8I5Y064
      Conserved Domains (5) summary
      cd09439
      Location:764 → 818
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1184 → 1577
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:1936 → 2104
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    6. XM_039107876.2 → XP_038963804.1  F-actin-monooxygenase MICAL3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1317 → 1710
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2069 → 2237
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    7. XM_039107873.2 → XP_038963801.1  F-actin-monooxygenase MICAL3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1335 → 1728
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2087 → 2255
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    8. XM_039107881.2 → XP_038963809.1  F-actin-monooxygenase MICAL3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1260 → 1653
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2012 → 2180
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    9. XM_039107877.2 → XP_038963805.1  F-actin-monooxygenase MICAL3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1315 → 1708
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2067 → 2235
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    10. XM_063286322.1 → XP_063142392.1  F-actin-monooxygenase MICAL3 isoform X10

    11. XM_039107879.2 → XP_038963807.1  F-actin-monooxygenase MICAL3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Related
      ENSRNOP00000087542.1
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2071 → 2217
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    12. XM_039107874.2 → XP_038963802.1  F-actin-monooxygenase MICAL3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2071 → 2239
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    13. XM_039107880.2 → XP_038963808.1  F-actin-monooxygenase MICAL3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2217
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    14. XM_039107875.2 → XP_038963803.1  F-actin-monooxygenase MICAL3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2239
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    15. XM_039107878.2 → XP_038963806.1  F-actin-monooxygenase MICAL3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2234
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    16. XM_039107869.2 → XP_038963797.1  F-actin-monooxygenase MICAL3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2256
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    17. XM_063286321.1 → XP_063142391.1  F-actin-monooxygenase MICAL3 isoform X1

    18. XM_039107871.2 → XP_038963799.1  F-actin-monooxygenase MICAL3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4K7
      Conserved Domains (5) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:1336 → 1729
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:2088 → 2256
      DUF3585; Protein of unknown function (DUF3585)
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    19. XM_063286324.1 → XP_063142394.1  F-actin-monooxygenase MICAL3 isoform X15

    20. XM_039107886.2 → XP_038963814.1  F-actin-monooxygenase MICAL3 isoform X16

      Conserved Domains (3) summary
      cd09439
      Location:290 → 344
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam05109
      Location:710 → 1103
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12130
      Location:1462 → 1630
      DUF3585; Protein of unknown function (DUF3585)

    21. XM_063286327.1 → XP_063142397.1  F-actin-monooxygenase MICAL3 isoform X20

    22. XM_063286326.1 → XP_063142396.1  F-actin-monooxygenase MICAL3 isoform X19

    23. XM_063286325.1 → XP_063142395.1  F-actin-monooxygenase MICAL3 isoform X18

    24. XM_039107887.2 → XP_038963815.1  F-actin-monooxygenase MICAL3 isoform X17

      Conserved Domains (3) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    25. XM_063286328.1 → XP_063142398.1  F-actin-monooxygenase MICAL3 isoform X22

    26. XM_063286330.1 → XP_063142400.1  F-actin-monooxygenase MICAL3 isoform X23

    27. XM_063286329.1 → XP_063142399.1  F-actin-monooxygenase MICAL3 isoform X23

    28. XM_039107888.2 → XP_038963816.1  F-actin-monooxygenase MICAL3 isoform X21

      Conserved Domains (3) summary
      cd09439
      Location:916 → 970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cd21251
      Location:515 → 625
      CH_MICAL3; calponin homology (CH) domain found in molecule interacting with CasL protein 3

    29. XM_063286332.1 → XP_063142402.1  F-actin-monooxygenase MICAL3 isoform X24

    30. XM_063286331.1 → XP_063142401.1  F-actin-monooxygenase MICAL3 isoform X24

    31. XM_063286334.1 → XP_063142404.1  F-actin-monooxygenase MICAL3 isoform X25

    32. XM_063286333.1 → XP_063142403.1  F-actin-monooxygenase MICAL3 isoform X25

    33. XM_063286335.1 → XP_063142405.1  F-actin-monooxygenase MICAL3 isoform X25

    RNA

    1. XR_010065679.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014189.1: Suppressed sequence

      Description
      NM_001014189.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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