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    SEC72 Sec63 complex subunit SEC72 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850999, updated on 17-May-2024

    Summary

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    Gene symbol
    SEC72
    Gene description
    Sec63 complex subunit SEC72
    Primary source
    FungiDB:YLR292C
    Locus tag
    YLR292C
    See related
    SGD:S000004283; AllianceGenome:SGD:S000004283; VEuPathDB:YLR292C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEC67; SIM2
    Summary
    Enables protein transmembrane transporter activity. Involved in posttranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum. Part of Sec62/Sec63 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SEC72 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (719789..720370, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ubiquinone biosynthesis protein COQ11 Neighboring gene translation initiation factor eIF2B subunit beta Neighboring gene Ran GTPase GSP1 Neighboring gene F1F0 ATP synthase subunit h

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex. Feldheim D, et al. J Cell Biol, 1994 Aug. PMID 8051213, Free PMC Article
    2. Novel β-structure of YLR301w from Saccharomyces cerevisiae. Kim KH, et al. Acta Crystallogr D Biol Crystallogr, 2012 May. PMID 22525751
    3. Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae. Fang H, et al. Mol Biol Cell, 1994 Sep. PMID 7841522, Free PMC Article
    4. The tetratricopeptide repeats of receptors involved in protein translocation across membranes. Schlegel T, et al. Mol Biol Evol, 2007 Dec. PMID 17905998
    5. Architecture of the active post-translational Sec translocon. Weng TH, et al. EMBO J, 2021 Feb 1. PMID 33305433, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    Sec63 complex subunit SEC72
    NP_013395.1
    • Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec66p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      719789..720370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182180.1 → NP_013395.1  TPA: Sec63 complex subunit SEC72 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYT8, P39742
      UniProtKB/TrEMBL
      A0A6L0YGH1, A7A1H5, B3RHH2, B5VNJ8, C7GVU5, C8ZDQ6, G2WJB6, N1P1I4
      Conserved Domains (2) summary
      PLN03088
      Location:143 → 189
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:139 → 169
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6N3Q_F.1
    7AFT_F.1
    7KAH_F.1
    7KAO_F.1
    P39742.3

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