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    Gprc5c G protein-coupled receptor, class C, group 5, member C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287805, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Gprc5cprovided by RGD
    Official Full Name
    G protein-coupled receptor, class C, group 5, member Cprovided by RGD
    Primary source
    RGD:1311408
    See related
    Ensembl:ENSRNOG00000003144 AllianceGenome:RGD:1311408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and activation of protein kinase activity. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in extracellular exosome; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human GPRC5C (G protein-coupled receptor class C group 5 member C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 230.0), Liver (RPKM 74.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gprc5c in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100385682..100407953)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (99886900..99908928)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103395222..103417360)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 19 Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene Cd300a molecule Neighboring gene CD300 molecule-like family member b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article
    2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor family C group 5 member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191591.2 → NP_001178520.2  G-protein coupled receptor family C group 5 member C precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K9B8, A0A8I5ZNK1
      Related
      ENSRNOP00000074938.2, ENSRNOT00000086924.2
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      100385682..100407953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247678.5 → XP_006247740.2  G-protein coupled receptor family C group 5 member C isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNK1, F1LRW5
      Related
      ENSRNOP00000004256.6
      Conserved Domains (1) summary
      cd15277
      Location:144 → 401
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    2. XM_006247682.4 → XP_006247744.2  G-protein coupled receptor family C group 5 member C isoform X2

      UniProtKB/Swiss-Prot
      Q3KRC4
      UniProtKB/TrEMBL
      A0A8I5ZNK1, B6ID02
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    3. XM_017597153.3 → XP_017452642.2  G-protein coupled receptor family C group 5 member C isoform X2

      UniProtKB/Swiss-Prot
      Q3KRC4
      UniProtKB/TrEMBL
      A0A8I5ZNK1, B6ID02
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    4. XM_006247681.5 → XP_006247743.2  G-protein coupled receptor family C group 5 member C isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNK1, A0A8I6ATM9
      Related
      ENSRNOP00000095514.1
      Conserved Domains (1) summary
      cd15277
      Location:70 → 327
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    5. XM_006247685.5 → XP_006247747.2  G-protein coupled receptor family C group 5 member C isoform X2

      UniProtKB/Swiss-Prot
      Q3KRC4
      UniProtKB/TrEMBL
      A0A8I5ZNK1, B6ID02
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KRC4.2 GenPept UniProtKB/Swiss-Prot:Q3KRC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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