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    Fcgrt Fc gamma receptor and transporter [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29558, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fcgrtprovided by RGD
    Official Full Name
    Fc gamma receptor and transporterprovided by RGD
    Primary source
    RGD:61811
    See related
    Ensembl:ENSRNOG00000020583 AllianceGenome:RGD:61811
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FcRn
    Summary
    Enables beta-2-microglobulin binding activity. Predicted to be involved in immune response. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human FCGRT (Fc fragment of IgG receptor and transporter). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 652.1), Spleen (RPKM 643.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fcgrt in Genome Data Viewer
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104710902..104720685, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95574436..95584171, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101086872..101096159, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 2 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene microRNA 150 Neighboring gene ribosomal protein S11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance. Yadav SPS, et al. Am J Physiol Renal Physiol, 2021 Jan 1. PMID 33283642, Free PMC Article
    2. Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding. Thorn M, et al. Birth Defects Res B Dev Reprod Toxicol, 2012 Oct. PMID 22969064
    3. Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine. Ladinsky MS, et al. Mol Biol Cell, 2012 Jul. PMID 22573886, Free PMC Article
    4. FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. He W, et al. Nature, 2008 Sep 25. PMID 18818657, Free PMC Article
    5. Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Sakagami M, et al. Pharm Res, 2006 Feb. PMID 16382279

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance.
      Title: Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance.
    2. significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn
      Title: Mechanism of increased clearance of glycated albumin by proximal tubule cells.
    3. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
      Title: The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
    4. Characterization and screening of IgG binding to the neonatal Fc receptor.
      Title: Characterization and screening of IgG binding to the neonatal Fc receptor.
    5. Fetal transfer of Avastins mutated in the portion of the antibody that binds the neonatal Fc receptor (FcRn) was tested in late gestation and was found to correlate with affinities of the mutant Avastin antibody to FcRn.
      Title: Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding.
    6. The suckling rat pup intestine is a mechanistic model of FcRn-IgG-mediated transcytosis
      Title: Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.
    7. multivesicular bodies function in IgG transport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum does not express FcRn or transport IgG.
      Title: Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine.
    8. N-glycans in FcRn contribute significantly to the steady-state membrane distribution and direction of IgG transport in polarized epithelia.
      Title: N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
    9. results present a complex picture in which Fc moves through networks of entangled tubular and irregular vesicles, only some of which are microtubule-associated, as it migrates to the basolateral surface
      Title: FcRn-mediated antibody transport across epithelial cells revealed by electron tomography.
    10. interactions between the tryptophan-based endocytosis signal, WLSL, contained within the cytoplasmic domain of the neonatal Fc receptor and the mu2 subunit of AP-2
      Title: Recognition of the tryptophan-based endocytosis signal in the neonatal Fc Receptor by the mu subunit of adaptor protein-2.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IgG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IgG receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables beta-2-microglobulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-2-microglobulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in humoral immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IgG receptor FcRn large subunit p51
    Names
    Fc fragment immunoglobulin G receptor
    Fc fragment of IgG receptor and transporter
    Fc fragment of IgG, receptor, transporter, alpha
    Fc receptor, IgG, alpha chain transporter
    igG Fc fragment receptor transporter alpha chain
    neonatal Fc receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033351.2 → NP_203502.1  IgG receptor FcRn large subunit p51 precursor

      See identical proteins and their annotated locations for NP_203502.1

      Status: PROVISIONAL

      Source sequence(s)
      M35495
      UniProtKB/Swiss-Prot
      P13599
      UniProtKB/TrEMBL
      A0A8L2QEY2, A6JAW9
      Conserved Domains (2) summary
      pfam00129
      Location:25 → 198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21011
      Location:199 → 291
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104710902..104720685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229043.4 → XP_006229105.1  IgG receptor FcRn large subunit p51 isoform X1

      See identical proteins and their annotated locations for XP_006229105.1

      UniProtKB/Swiss-Prot
      P13599
      UniProtKB/TrEMBL
      A0A8L2QEY2, A6JAW9
      Related
      ENSRNOP00000093291.1
      Conserved Domains (2) summary
      pfam00129
      Location:25 → 198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21011
      Location:199 → 291
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

    2. XM_039109580.1 → XP_038965508.1  IgG receptor FcRn large subunit p51 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKP0
      Related
      ENSRNOP00000093469.1, ENSRNOT00000104770.1
      Conserved Domains (2) summary
      cd21011
      Location:110 → 199
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
      cl08246
      Location:25 → 110
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. XM_017589060.2 → XP_017444549.1  IgG receptor FcRn large subunit p51 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QEY2
      Conserved Domains (2) summary
      cd21011
      Location:170 → 262
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
      cl08246
      Location:1 → 169
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    4. XM_039109565.2 → XP_038965493.1  IgG receptor FcRn large subunit p51 isoform X1

      UniProtKB/Swiss-Prot
      P13599
      UniProtKB/TrEMBL
      A0A8L2QEY2, A6JAW9
      Conserved Domains (2) summary
      pfam00129
      Location:25 → 198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21011
      Location:199 → 291
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

    5. XM_063287635.1 → XP_063143705.1  IgG receptor FcRn large subunit p51 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKP0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13599.1 GenPept UniProtKB/Swiss-Prot:P13599

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