TRIM24 tripartite motif containing 24 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM24provided by HGNC
Official Full Name: tripartite motif containing 24provided by HGNC
Primary source: HGNC:HGNC:11812
See related: Ensembl:ENSG00000122779 MIM:603406; AllianceGenome:HGNC:11812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
Summary: The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 19.9), ovary (RPKM 16.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q33-q34

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (138460259..138589996)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (139769953..139899677)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (138145004..138274741)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module.
Title: Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module.
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Title: TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.
Title: TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.
miR-339-3p inhibits cell growth and epithelial-mesenchymal transition in nasopharyngeal carcinoma by modulating the KAT6A/TRIM24 axis.
Title: miR-339-3p inhibits cell growth and epithelial-mesenchymal transition in nasopharyngeal carcinoma by modulating the KAT6A/TRIM24 axis.
STAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment.
Title: STAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment.
High expression of TRIM24 predicts worse prognosis and promotes proliferation and metastasis of epithelial ovarian cancer.
Title: High expression of TRIM24 predicts worse prognosis and promotes proliferation and metastasis of epithelial ovarian cancer.
KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
Title: KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
Overexpression of the TRIM24 E3 Ubiquitin Ligase is Linked to Genetic Instability and Predicts Unfavorable Prognosis in Prostate Cancer.
Title: Overexpression of the TRIM24 E3 Ubiquitin Ligase is Linked to Genetic Instability and Predicts Unfavorable Prognosis in Prostate Cancer.
E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1beta-mediated pyroptosis in endometriosis.
Title: E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1β-mediated pyroptosis in endometriosis.
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
Title: Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat binds to TIF1 in 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S1449 (e-PCR)
- UniSTS:67114

D7S2560 (e-PCR)
- UniSTS:57399

RH102050 (e-PCR)
- UniSTS:96384

D7S2560 (e-PCR)
- UniSTS:6017

D7S3181 (e-PCR)
- UniSTS:225964

D7S3185 (e-PCR)
- UniSTS:225967

D7S3186 (e-PCR)
- UniSTS:225968

RH40971 (e-PCR)
- UniSTS:91852

SHGC-172979 (e-PCR)
- UniSTS:185295

RH46506 (e-PCR)
- UniSTS:17360

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in regulation of vitamin D receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of euchromatin	IEA Inferred from Electronic Annotation more info
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perichromatin fibrils	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription intermediary factor 1-alpha

Names: E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; transcriptional intermediary factor 1

NP_003843.3

EC 2.3.2.27

NP_056989.2

EC 2.3.2.27

XP_024302749.1

EC 2.3.2.27

XP_054215260.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023286.2 RefSeqGene

Range

5002..134739

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003852.4 → NP_003843.3 transcription intermediary factor 1-alpha isoform b

See identical proteins and their annotated locations for NP_003843.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC008265, AC013429, AF119042, AK075306, BC028689, CB988362

Consensus CDS

CCDS47720.1

UniProtKB/TrEMBL

B4DYZ9

Related

ENSP00000390829.2, ENST00000415680.6

Conserved Domains (6) summary

cd05502
Location:866 → 973

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:266 → 392

BBC; B-Box C-terminal domain

smart00336
Location:158 → 194

BBOX; B-Box-type zinc finger

cd00021
Location:221 → 259

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15622
Location:794 → 836

PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)

cd16764
Location:53 → 134

RING-HC_TIF1alpha; RING finger, HC subclass, found in transcription inknown asiary factor 1-alpha (TIF1-alpha)
NM_015905.3 → NP_056989.2 transcription intermediary factor 1-alpha isoform a

See identical proteins and their annotated locations for NP_056989.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AA844662, AC008265, AC013429, AK075306, BC028689, CB988362

Consensus CDS

CCDS5847.1

UniProtKB/Swiss-Prot

A4D1R7, A4D1R8, O15164, O95854

UniProtKB/TrEMBL

B4DYZ9

Related

ENSP00000340507.4, ENST00000343526.9

Conserved Domains (7) summary

cd05502
Location:900 → 1007

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:266 → 392

BBC; B-Box C-terminal domain

smart00336
Location:158 → 194

BBOX; B-Box-type zinc finger

cd00021
Location:221 → 259

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15622
Location:828 → 870

PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)

cd16764
Location:53 → 134

RING-HC_TIF1alpha; RING finger, HC subclass, found in transcription inknown asiary factor 1-alpha (TIF1-alpha)

cl25764
Location:430 → 564

PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

138460259..138589996

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446981.2 → XP_024302749.1 transcription intermediary factor 1-alpha isoform X1

UniProtKB/TrEMBL

B4DYZ9

Conserved Domains (7) summary

cd05502
Location:881 → 988

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:247 → 373

BBC; B-Box C-terminal domain

smart00336
Location:139 → 175

BBOX; B-Box-type zinc finger

cd00021
Location:202 → 240

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15622
Location:809 → 851

PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)

cl17238
Location:60 → 115

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

cl25764
Location:416 → 545

PAT1; Topoisomerase II-associated protein PAT1