PLXNB1 plexin B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLXNB1provided by HGNC
Official Full Name: plexin B1provided by HGNC
Primary source: HGNC:HGNC:9103
See related: Ensembl:ENSG00000164050 MIM:601053; AllianceGenome:HGNC:9103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SEP; PLXN5; PLEXIN-B1
Summary: Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Is integral component of plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in skin (RPKM 13.8), kidney (RPKM 13.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.31

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (48403854..48430310, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (48431864..48458348, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (48445261..48471495, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Semaphorin4A promotes lung cancer by activation of NF-kappaB pathway mediated by PlexinB1.
Title: Semaphorin4A promotes lung cancer by activation of NF-κB pathway mediated by PlexinB1.
Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder.
Title: Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder.
PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism.
Title: PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism.
Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by activating Pyk2-PI3K-AKT pathway.
Title: Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by activating Pyk2-PI3K-AKT pathway.
Plexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme.
Title: Plexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme.
PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor.
Title: PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor.
Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling.
Title: Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling.
Decreased expression of sema4D and Plexin-B1 may be responsible for the deficiency in Met signalling and the development of preeclampsia.
Title: Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia.
Plexin-B1 level showed a significant positive correlation both with overall survival and disease free survival of Caucasian breast cancer patients
Title: Association between prognosis and SEMA4D/Plexin-B1 expression in various malignancies: A meta-analysis.
Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity.
Title: Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC152287P2 (e-PCR)
- UniSTS:271214

Plxnb1 (e-PCR), detects polymorphism
- UniSTS:546955

SHGC-30574 (e-PCR)
- UniSTS:47771

STS-D29212 (e-PCR)
- UniSTS:48323

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activating protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables semaphorin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables semaphorin receptor activity	TAS Traceable Author Statement more info	PubMed
enables semaphorin receptor binding	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in inhibitory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in semaphorin-plexin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of semaphorin receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of semaphorin receptor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of semaphorin receptor complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: plexin-B1

Names: plexin 5; semaphorin receptor SEP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130082.3 → NP_001123554.1 plexin-B1 precursor

See identical proteins and their annotated locations for NP_001123554.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AB007867, AC134772, BC066773

Consensus CDS

CCDS2765.1

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93

Related

ENSP00000296440.6, ENST00000296440.11

Conserved Domains (10) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:681 → 839

PHA03247; large tegument protein UL36; Provisional

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2102

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:921 → 1020

TIG_2; TIG domain found in plexin
NM_002673.6 → NP_002664.2 plexin-B1 precursor

See identical proteins and their annotated locations for NP_002664.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AB007867, AC134772, BC066773

Consensus CDS

CCDS2765.1

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93

Related

ENSP00000351338.4, ENST00000358536.8

Conserved Domains (10) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:681 → 839

PHA03247; large tegument protein UL36; Provisional

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2102

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:921 → 1020

TIG_2; TIG domain found in plexin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

48403854..48430310 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448333.1 → XP_047304289.1 plexin-B1 isoform X2

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
XM_011533835.2 → XP_011532137.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_011532137.1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_047448335.1 → XP_047304291.1 plexin-B1 isoform X2

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
XM_011533836.2 → XP_011532138.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_011532138.1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_011533833.3 → XP_011532135.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_011532135.1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_047448331.1 → XP_047304287.1 plexin-B1 isoform X2

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
XM_017006630.2 → XP_016862119.1 plexin-B1 isoform X1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_047448332.1 → XP_047304288.1 plexin-B1 isoform X2

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
XM_011533837.2 → XP_011532139.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_011532139.1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_011533834.2 → XP_011532136.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_011532136.1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_047448334.1 → XP_047304290.1 plexin-B1 isoform X2

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
XM_047448330.1 → XP_047304286.1 plexin-B1 isoform X1
XM_017006631.2 → XP_016862120.1 plexin-B1 isoform X2

UniProtKB/Swiss-Prot

A6H8Y2, O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93

Conserved Domains (10) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:681 → 839

PHA03247; large tegument protein UL36; Provisional

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2102

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:921 → 1020

TIG_2; TIG domain found in plexin
XM_024453600.2 → XP_024309368.1 plexin-B1 isoform X1

Conserved Domains (8) summary

cd11275
Location:28 → 480

Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:1162 → 1249

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:1070 → 1161

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1252 → 1376

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam08337
Location:1562 → 2103

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl26464
Location:681 → 839

Atrophin-1; Atrophin-1 family
XM_047448336.1 → XP_047304292.1 plexin-B1 isoform X3