yrk Yes-related kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: yrkprovided by ZNC
Official Full Name: Yes-related kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9517
See related: Ensembl:ENSDARG00000004378 AllianceGenome:ZFIN:ZDB-GENE-030131-9517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj84d04; zgc:92165; wu:fj84d04
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within macrophage chemotaxis. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in blood island; cardiovascular system; head; mesoderm; and post-vent region. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (43392682..43432415)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (43797085..43836818)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase Fgr

Names: Yes-relayed kinase

NP_997946.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365553.1 → NP_001352482.1 tyrosine-protein kinase Fgr isoform 1

Status: VALIDATED

Source sequence(s)

CU104776

Conserved Domains (3) summary

cd14203
Location:266 → 513

PTKc_Src_Fyn_like; Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases

cl15255
Location:136 → 234

SH2; Src homology 2 (SH2) domain

cl17036
Location:76 → 133

SH3; Src Homology 3 domain superfamily
NM_212781.2 → NP_997946.1 tyrosine-protein kinase Fgr isoform 2

See identical proteins and their annotated locations for NP_997946.1

Status: VALIDATED

Source sequence(s)

CU104776

UniProtKB/TrEMBL

A0A8M1PFN7, Q8AWF1

Related

ENSDARP00000145924.1, ENSDART00000188236.1

Conserved Domains (4) summary

cd10367
Location:136 → 236

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cd14203
Location:263 → 510

PTKc_Src_Fyn_like; Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases

pfam07714
Location:259 → 508

Pkinase_Tyr; Protein tyrosine kinase

cl17036
Location:76 → 133

SH3; Src Homology 3 domain superfamily