mier1b mesoderm induction early response 1b, transcriptional regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mier1bprovided by ZNC
Official Full Name: mesoderm induction early response 1b, transcriptional regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-170
See related: Ensembl:ENSDARG00000001447 AllianceGenome:ZFIN:ZDB-GENE-070705-170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi26b03; wu:fi26b03; si:ch211-273k1.3
Summary: Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Orthologous to human MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (5811486..5836130, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (5899604..5924248, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mesoderm induction early response protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291343.1 → NP_001278272.1 mesoderm induction early response protein 1b

Status: VALIDATED

Source sequence(s)

BX001029

UniProtKB/TrEMBL

A0A8M1P0M2, E9QHV5

Related

ENSDARP00000122061.1, ENSDART00000142545.3

Conserved Domains (3) summary

smart00717
Location:286 → 331

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:286 → 330

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:180 → 230

ELM2; ELM2 domain