rcor1 REST corepressor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rcor1provided by ZNC
Official Full Name: REST corepressor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050506-79
See related: Ensembl:ENSDARG00000031434 AllianceGenome:ZFIN:ZDB-GENE-050506-79
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6904264; zgc:158607; si:dkey-46n18.7
Summary: Predicted to enable transcription corepressor activity. Acts upstream of or within hemopoiesis and regulation of retinoic acid biosynthetic process. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in eye; head; intestine; and optic tectum. Orthologous to human RCOR1 (REST corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (29251662..29271135, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (29234699..29254172, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi71e03.x1 (e-PCR)
- UniSTS:197899

fc55c01.y1 (e-PCR)
- UniSTS:194076

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of retinoic acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: REST corepressor 1

Names: corest

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080041.1 → NP_001073510.1 REST corepressor 1

See identical proteins and their annotated locations for NP_001073510.1

Status: PROVISIONAL

Source sequence(s)

BC129322

UniProtKB/TrEMBL

A1L228

Related

ENSDARP00000094994.3, ENSDART00000104219.4

Conserved Domains (4) summary

smart00717
Location:354 → 400

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:355 → 398

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:57 → 109

ELM2; ELM2 domain

cl21498
Location:145 → 189

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...