snai2 snail family zinc finger 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: snai2provided by ZNC
Official Full Name: snail family zinc finger 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030326-6
See related: Ensembl:ENSDARG00000040046 AllianceGenome:ZFIN:ZDB-GENE-030326-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slug; cb147; cb355; sb:cb355; sb:cb569; zgc:92564; id:ibd5003; wu:fb83e12; wu:fd19g11
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; neural crest; and splanchnocranium. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (35387494..35393535)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (35501013..35507176)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Snai2 morphants fail to initiate hematopoietic stem cells specification and show defects in the somitic niche of migrating hematopoietic stem cells precursors.
Title: Zebrafish snai2 mutants fail to phenocopy morphant phenotypes.
Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
Title: Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd19g11.x1 (e-PCR)
- UniSTS:195243

AI722560 (e-PCR)
- UniSTS:206003

AI722148 (e-PCR)
- UniSTS:206028

fb83e12.x1 (e-PCR)
- UniSTS:203495

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein SNAI2

Names: snail homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008581.1 → NP_001008581.1 zinc finger protein SNAI2

See identical proteins and their annotated locations for NP_001008581.1

Status: PROVISIONAL

Source sequence(s)

BC086969

UniProtKB/TrEMBL

A0A8M1N391, Q5PQY5

Related

ENSDARP00000058570.6, ENSDART00000058571.7

Conserved Domains (2) summary

sd00017
Location:176 → 196

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:189 → 212

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

35387494..35393535

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009297590.3 → XP_009295865.1 zinc finger protein SNAI2 isoform X1

UniProtKB/TrEMBL

A0A8M3AZA3

Conserved Domains (2) summary

sd00017
Location:167 → 187

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:180 → 203

zf-H2C2_2; Zinc-finger double domain