pdgfab platelet-derived growth factor alpha polypeptide b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdgfabprovided by ZNC
Official Full Name: platelet-derived growth factor alpha polypeptide bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-124
See related: Ensembl:ENSDARG00000098578 AllianceGenome:ZFIN:ZDB-GENE-060929-124
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc32c12; zgc:153249
Summary: Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of protein autophosphorylation. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in endoderm; mouth; pharyngeal arch; pharyngeal endoderm; and pharyngeal pouch. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (12924927..12970468, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (12773481..12819035, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet-derived growth factor alpha polypeptide b

Names: platelet derived growth factor alpha b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076757.1 → NP_001070225.1 platelet-derived growth factor alpha polypeptide b precursor

See identical proteins and their annotated locations for NP_001070225.1

Status: PROVISIONAL

Source sequence(s)

BC124288

UniProtKB/TrEMBL

Q08CD2

Related

ENSDARP00000140240.1, ENSDART00000158747.2

Conserved Domains (2) summary

pfam00341
Location:105 → 189

PDGF; PDGF/VEGF domain

pfam04692
Location:22 → 104

PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

12924927..12970468 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163736.4 → XP_005163793.1 platelet-derived growth factor alpha polypeptide b isoform X1

UniProtKB/TrEMBL

A0A8M2BAV6

Conserved Domains (2) summary

pfam00341
Location:105 → 189

PDGF; PDGF/VEGF domain

pfam04692
Location:22 → 104

PDGF_N; Platelet-derived growth factor, N terminal region