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    stim1a stromal interaction molecule 1a [ Danio rerio (zebrafish) ]

    Gene ID: 556360, updated on 25-Apr-2024

    Summary

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    Official Symbol
    stim1aprovided by ZNC
    Official Full Name
    stromal interaction molecule 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-914
    See related
    Ensembl:ENSDARG00000060723 AllianceGenome:ZFIN:ZDB-GENE-060503-914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-24p1.5
    Summary
    Predicted to enable calcium channel regulator activity and calcium ion binding activity. Acts upstream of with a positive effect on axon extension involved in axon guidance. Predicted to be located in membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Stormorken syndrome; immunodeficiency 10; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See stim1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (38221146..38297737)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (38319556..38394767)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha 10a Neighboring gene ras homolog family member Ga Neighboring gene si:dkey-24p1.6 Neighboring gene transient receptor potential cation channel subfamily C member 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones. Pavez M, et al. J Neurosci, 2019 Jun 26. PMID 31023836, Free PMC Article
    2. SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos. Chan CM, et al. Zygote, 2016 Dec. PMID 27702423
    3. STIM1 activation of adenylyl cyclase 6 connects Ca(2+) and cAMP signaling during melanogenesis. Motiani RK, et al. EMBO J, 2018 Mar 1. PMID 29311116, Free PMC Article
    4. Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Wasilewska I, et al. Genes (Basel), 2019 Mar 18. PMID 30889933, Free PMC Article
    5. Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. Gupta RK, et al. Int J Mol Sci, 2020 Aug 27. PMID 32867296, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stim1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
      Title: SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stromal interaction molecule 1; stromal interaction molecule 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044799.1 → NP_001038264.1  stromal interaction molecule 1a precursor

      Status: PROVISIONAL

      Source sequence(s)
      BX072550
      UniProtKB/TrEMBL
      A0A8M1N9C0, Q1LY88
      Related
      ENSDARP00000109796.2, ENSDART00000122134.4
      Conserved Domains (3) summary
      cd09573
      Location:122 → 195
      SAM_STIM1; SAM domain of STIM1 subfamily proteins
      pfam16533
      Location:338 → 435
      SOAR; STIM1 Orai1-activating region
      cl23720
      Location:227 → 330
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      38221146..38297737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173392.4 → XP_005173449.1  stromal interaction molecule 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKP3
      Conserved Domains (3) summary
      cd09573
      Location:122 → 195
      SAM_STIM1; SAM domain of STIM1 subfamily proteins
      pfam16533
      Location:338 → 435
      SOAR; STIM1 Orai1-activating region
      cl23720
      Location:227 → 330
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_009291871.3 → XP_009290146.1  stromal interaction molecule 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8RIM0, A0A8M3AHN3
      Related
      ENSDARP00000145787.1, ENSDART00000188149.1
      Conserved Domains (3) summary
      pfam16533
      Location:338 → 435
      SOAR; STIM1 Orai1-activating region
      cl15755
      Location:122 → 195
      SAM_superfamily; SAM (Sterile alpha motif )
      cl23720
      Location:227 → 330
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_005173393.4 → XP_005173450.1  stromal interaction molecule 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BKR0
      Conserved Domains (3) summary
      cd09573
      Location:122 → 195
      SAM_STIM1; SAM domain of STIM1 subfamily proteins
      pfam16533
      Location:338 → 435
      SOAR; STIM1 Orai1-activating region
      cl23720
      Location:227 → 330
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version

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