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    l1cama L1 cell adhesion molecule, paralog a [ Danio rerio (zebrafish) ]

    Gene ID: 30634, updated on 7-Apr-2024

    Summary

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    Official Symbol
    l1camaprovided by ZNC
    Official Full Name
    L1 cell adhesion molecule, paralog aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-10
    See related
    Ensembl:ENSDARG00000007149 AllianceGenome:ZFIN:ZDB-GENE-990415-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    L1.2; nadl1.2; sb:eu320; sb:eu917; NCAM-L1.2; wu:fq26g05
    Summary
    Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of axon extension; and synapse organization. Predicted to act upstream of or within cell adhesion; cell differentiation; and nervous system development. Predicted to be located in axonal growth cone. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in gut; nervous system; presumptive enteric nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See l1cama in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28582784..28682202)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28656243..28755830)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Neighboring gene microRNA let7g-2 Neighboring gene microRNA let7h Neighboring gene RIB43A domain with coiled-coils 1 Neighboring gene structural maintenance of chromosomes 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish. Chen T, et al. Restor Neurol Neurosci, 2016. PMID 26889968
    2. Use of PCR template-derived probes prevents off-target whole mount in situ hybridization in transgenic zebrafish. Cha YR, et al. Zebrafish, 2012 Jun. PMID 22715949, Free PMC Article
    3. A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish. Sahu S, et al. Mol Neurobiol, 2018 Jan. PMID 28070857
    4. A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity. Heanue TA, et al. PLoS Genet, 2016 Nov. PMID 27902697, Free PMC Article
    5. Semaphorin3D regulates axon axon interactions by modulating levels of L1 cell adhesion molecule. Wolman MA, et al. J Neurosci, 2007 Sep 5. PMID 17804626, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that L1.2 contributes to spinal cord regeneration in adult zebrafish.
      Title: L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule L1.2
    Names
    neural adhesion molecule L1.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131361.2 → NP_571436.2  neural cell adhesion molecule L1.2

      Status: VALIDATED

      Source sequence(s)
      BX664745, CR354431
      UniProtKB/TrEMBL
      A0A8M9PKJ8, F1R9X3, Q6U7I4
      Related
      ENSDARP00000005473.6, ENSDART00000020296.7
      Conserved Domains (6) summary
      smart00410
      Location:450 → 526
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:547 → 616
      Ig; Immunoglobulin domain
      cd05733
      Location:69 → 144
      Ig_L1-CAM_like; Immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      pfam13882
      Location:1150 → 1234
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:147 → 241
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      28582784..28682202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162225.4 → XP_005162282.1  neural cell adhesion molecule L1.2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B9E7, Q6U7I4
      Conserved Domains (7) summary
      cd00096
      Location:547 → 616
      Ig; Immunoglobulin domain
      cd05733
      Location:69 → 144
      Ig6_L1-CAM_like; Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00408
      Location:454 → 517
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:263 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1150 → 1235
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:147 → 241
      Ig; Immunoglobulin domain

    2. XM_021469729.1 → XP_021325404.1  neural cell adhesion molecule L1.2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKJ8, F1R9X3, Q6U7I4
      Conserved Domains (6) summary
      smart00410
      Location:450 → 526
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:547 → 616
      Ig; Immunoglobulin domain
      cd05733
      Location:69 → 144
      Ig_L1-CAM_like; Immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      pfam13882
      Location:1150 → 1234
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:147 → 241
      Ig; Immunoglobulin domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395155.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      543146..640557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90479.1 GenPept UniProtKB/Swiss-Prot:Q90479

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