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    zgc:153867 zgc:153867 [ Danio rerio (zebrafish) ]

    Gene ID: 337226, updated on 27-Mar-2024

    Summary

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    Official Symbol
    zgc:153867provided by ZNC
    Official Full Name
    zgc:153867provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9170
    See related
    Ensembl:ENSDARG00000033738 AllianceGenome:ZFIN:ZDB-GENE-030131-9170
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MLC3SM; fb02e09; wu:fa98e09; wu:fb02e09; hm:zehn1575
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human MYL6 (myosin light chain 6) and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See zgc:153867 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28374517..28388513)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28448069..28461972)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat containing 5b Neighboring gene neuronal differentiation 4 Neighboring gene complement component 1, q subcomponent-like 4 Neighboring gene uncharacterized LOC101882861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Lekven AC, et al. Dev Biol, 2003 Feb 15. PMID 12591239
    2. Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Chen Z, et al. Cardiovasc Res, 2008 Jul 1. PMID 18343897, Free PMC Article
    3. Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Frohnhöfer HG, et al. Biol Open, 2016 Jun 15. PMID 27215328, Free PMC Article
    4. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Zhao S, et al. Proteomics, 2012 Jan. PMID 22140076
    5. Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung. Zheng W, et al. PLoS One, 2011. PMID 21887364, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain alkali, smooth-muscle isoform; uncharacterized protein LOC337226

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213638.1 → NP_998803.1  uncharacterized protein LOC337226

      See identical proteins and their annotated locations for NP_998803.1

      Status: PREDICTED

      Source sequence(s)
      AY391442
      UniProtKB/TrEMBL
      B2GQW5, F6PB68, Q6TNS5
      Related
      ENSDARP00000025083.7, ENSDART00000014983.9
      Conserved Domains (3) summary
      PTZ00184
      Location:5 → 150
      PTZ00184; calmodulin; Provisional
      smart00054
      Location:11 → 39
      EFh; EF-hand, calcium binding motif
      cd00051
      Location:88 → 149
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      28374517..28388513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469755.1 → XP_021325430.1  myosin light chain alkali, smooth-muscle isoform isoform X2

      UniProtKB/TrEMBL
      A0A8M9PWC9
      Conserved Domains (1) summary
      cl25352
      Location:60 → 208
      EFh_PEF; The penta-EF hand (PEF) family

    2. XM_021469754.1 → XP_021325429.1  myosin light chain alkali, smooth-muscle isoform isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKL9
      Related
      ENSDARP00000120093.1, ENSDART00000144240.3
      Conserved Domains (1) summary
      cl25352
      Location:60 → 208
      EFh_PEF; The penta-EF hand (PEF) family

    3. XM_017353524.2 → XP_017209013.1  myosin light chain alkali, smooth-muscle isoform isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z3P2

    4. XM_005162231.3 → XP_005162288.3  myosin light chain alkali, smooth-muscle isoform isoform X3

      UniProtKB/TrEMBL
      A0A8M2B9A6
      Conserved Domains (1) summary
      cl25352
      Location:51 → 196
      EFh_PEF; The penta-EF hand (PEF) family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395155.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      342967..354077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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