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    ndub-3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 174428, updated on 25-Apr-2024

    Summary

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    Gene symbol
    ndub-3
    Gene description
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
    Primary source
    WormBase:WBGene00007684
    Locus tag
    CELE_C18E9.4
    See related
    AllianceGenome:WB:WBGene00007684
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be integral component of membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 25. Orthologous to human NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ndub-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (8964242..8964890, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Vesicle transport protein Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene Translocation protein SEC62 Neighboring gene SUZ domain-containing protein;Suppressor of zyg-1 protein 20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
    NP_495907.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8964242..8964890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063506.6 → NP_495907.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18095
      Conserved Domains (1) summary
      pfam08122
      Location:39 → 95
      NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family
    Nucleotide Protein
    Heading Accession and Version

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