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    asp-1 Aspartic protease 1 [ Caenorhabditis elegans ]

    Gene ID: 180251, updated on 22-May-2024

    Summary

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    Gene symbol
    asp-1
    Gene description
    Aspartic protease 1
    Primary source
    WormBase:WBGene00000214
    Locus tag
    CELE_Y39B6A.20
    See related
    AllianceGenome:WB:WBGene00000214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell death. Located in cytoplasm and external side of apical plasma membrane. Is expressed in intestine. Orthologous to several human genes including CTSE (cathepsin E); PGA5 (pepsinogen A5); and PGC (progastricsin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See asp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_003283.11 (19049562..19050752, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Peptidase A1 domain-containing protein Neighboring gene pseudo Neighboring gene tRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans: A Genetic Guide to Parasitic Nematode Biology. Bird DM, et al. J Nematol, 1998 Sep. PMID 19274223, Free PMC Article
    2. Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1). Zhang F, et al. PLoS Pathog, 2016 Jan. PMID 26795495, Free PMC Article
    3. Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans. Mádi A, et al. Biochim Biophys Acta, 2008 Nov. PMID 18620082
    4. First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Lochnit G, et al. Biol Chem, 2006 Oct-Nov. PMID 17081123
    5. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. Tcherepanova I, et al. J Biol Chem, 2000 Aug 25. PMID 10854422

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aspartic protease 1
    NP_741677.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19049562..19050752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171587.6 → NP_741677.1  Aspartic protease 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEI4, O76830
      Conserved Domains (2) summary
      pfam00026
      Location:67 → 391
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:17 → 45
      A1_Propeptide; A1 Propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEI4.1

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