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    agt-1 Methylated-DNA--protein-cysteine methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 190454, updated on 12-Jun-2024

    Summary

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    Gene symbol
    agt-1
    Gene description
    Methylated-DNA--protein-cysteine methyltransferase
    Locus tag
    CELE_Y62E10A.5
    See related
    AllianceGenome:WB:WBGene00000093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables damaged DNA binding activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in DNA dealkylation involved in DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See agt-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (13368276..13369412, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;Serpentine Receptor, class SX Neighboring gene Large ribosomal subunit protein P2 Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene Protein kish

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel DNA repair alkyltransferase from Caenorhabditis elegans. Kanugula S, et al. Environ Mol Mutagen, 2001. PMID 11746760
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Methylated-DNA--protein-cysteine methyltransferase
    NP_001041054.1
    • Confirmed by transcript evidence
    NP_001041055.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13368276..13369412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047589.3 → NP_001041054.1  Methylated-DNA--protein-cysteine methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1Y0
      Conserved Domains (1) summary
      pfam01035
      Location:88 → 168
      DNA_binding_1; 6-O-methylguanine DNA methyltransferase, DNA binding domain

    2. NM_001047590.4 → NP_001041055.1  Methylated-DNA--protein-cysteine methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2HQK2
      Conserved Domains (1) summary
      pfam01035
      Location:46 → 126
      DNA_binding_1; 6-O-methylguanine DNA methyltransferase, DNA binding domain
    Nucleotide Protein
    Heading Accession and Version

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