CCL28 C-C motif chemokine ligand 28 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCL28provided by HGNC
Official Full Name: C-C motif chemokine ligand 28provided by HGNC
Primary source: HGNC:HGNC:17700
See related: Ensembl:ENSG00000151882 MIM:605240; AllianceGenome:HGNC:17700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEC; CCK1; SCYA28
Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Expression: Biased expression in salivary gland (RPKM 40.6), colon (RPKM 10.6) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (43356975..43412391, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (43609806..43665221, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (43376747..43412493, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
Title: Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
LncRNA H19 aggravates primary graft dysfunction after lung transplantation via KLF5-mediated activation of CCL28.
Title: LncRNA H19 aggravates primary graft dysfunction after lung transplantation via KLF5-mediated activation of CCL28.
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.
Title: Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.
Serum CCL28 as a biomarker for diagnosis and evaluation of Sjogren's syndrome.
Title: Serum CCL28 as a biomarker for diagnosis and evaluation of Sjögren's syndrome.
Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes.
Title: Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes.
CCL28 Downregulation Attenuates Pancreatic Cancer Progression Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms.
Title: CCL28 Downregulation Attenuates Pancreatic Cancer Progression Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms.
Knockdown of CCL28 inhibits endometriosis stromal cell proliferation and invasion via ERK signaling pathway inactivation.
Title: Knockdown of CCL28 inhibits endometriosis stromal cell proliferation and invasion via ERK signaling pathway inactivation.
Expression of Chemokine CCL28 in Ulcerative Colitis Patients.
Title: Expression of Chemokine CCL28 in Ulcerative Colitis Patients.
Hypoxia Induces Overexpression of CCL28 to Recruit Treg Cells to Enhance Angiogenesis in Lung Adenocarcinoma.
Title: Hypoxia Induces Overexpression of CCL28 to Recruit Treg Cells to Enhance Angiogenesis in Lung Adenocarcinoma.
this review discusses the role of CCL28 in innate and adaptive immunity
Title: CCL28 chemokine: An anchoring point bridging innate and adaptive immunity.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte tethering or rolling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-C motif chemokine 28

Names: CC chemokine CCL28; chemokine (C-C motif) ligand 28; mucosae-associated epithelial chemokine; small inducible cytokine A28; small inducible cytokine subfamily A (Cys-Cys), member 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301873.2 → NP_001288802.1 C-C motif chemokine 28 isoform a precursor

See identical proteins and their annotated locations for NP_001288802.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC025457, AF110384, BX486632

Consensus CDS

CCDS3944.1

UniProtKB/Swiss-Prot

D7RIE7, Q9NRJ3

UniProtKB/TrEMBL

A0N0Q3

Related

ENSP00000426424.1, ENST00000489442.5

Conserved Domains (1) summary

pfam00048
Location:28 → 86

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
NM_001301874.2 → NP_001288803.1 C-C motif chemokine 28 isoform a precursor

See identical proteins and their annotated locations for NP_001288803.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AF266504, BX486632

Consensus CDS

CCDS3944.1

UniProtKB/Swiss-Prot

D7RIE7, Q9NRJ3

UniProtKB/TrEMBL

A0N0Q3

Conserved Domains (1) summary

pfam00048
Location:28 → 86

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
NM_001301875.2 → NP_001288804.1 C-C motif chemokine 28 isoform b

See identical proteins and their annotated locations for NP_001288804.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate promoter, as evidenced by epigenomic data, and has an alternate 5' terminal exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC025457, CD671712

Consensus CDS

CCDS78006.1

UniProtKB/TrEMBL

D6RC73

Related

ENSP00000422369.1, ENST00000513525.1

Conserved Domains (1) summary

pfam00048
Location:2 → 39

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
NM_148672.3 → NP_683513.1 C-C motif chemokine 28 isoform a precursor

See identical proteins and their annotated locations for NP_683513.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC025457, BX486632

Consensus CDS

CCDS3944.1

UniProtKB/Swiss-Prot

D7RIE7, Q9NRJ3

UniProtKB/TrEMBL

A0N0Q3

Related

ENSP00000354416.4, ENST00000361115.4

Conserved Domains (1) summary

pfam00048
Location:28 → 86

IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

43356975..43412391 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_427660.3 RNA Sequence
XR_925633.3 RNA Sequence
XR_007058612.1 RNA Sequence
XR_007058610.1 RNA Sequence
XR_007058611.1 RNA Sequence
XR_007058613.1 RNA Sequence
XR_241706.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

43609806..43665221 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_008487136.1 RNA Sequence
XR_008487134.1 RNA Sequence
XR_008487137.1 RNA Sequence
XR_008487139.1 RNA Sequence
XR_008487138.1 RNA Sequence
XR_008487140.1 RNA Sequence
XR_008487135.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019846.3: Suppressed sequence

Description

NM_019846.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.