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    let-765 Protein strawberry notch homolog [ Caenorhabditis elegans ]

    Gene ID: 175934, updated on 19-Jun-2024

    Summary

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    Gene symbol
    let-765
    Gene description
    Protein strawberry notch homolog
    Locus tag
    CELE_F20H11.2
    See related
    AllianceGenome:WB:WBGene00002889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of Ras protein signal transduction; and vulval cell fate specification. Located in nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and P7.p hermaphrodite. Orthologous to several human genes including SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See let-765 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (6592525..6601173, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene D-aspartate oxidase 3 Neighboring gene Differentially expressed in FDCP 8 homolog Neighboring gene ncRNA Neighboring gene Malate dehydrogenase, mitochondrial Neighboring gene Protein-tyrosine phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines. Jung B, et al. Plant J, 2011 Mar. PMID 21235647
    2. Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III. Stewart HI, et al. Mol Gen Genet, 1998 Nov. PMID 9862482
    3. Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage. Simon F, et al. PLoS Genet, 2009 Aug. PMID 19662164, Free PMC Article
    4. A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans. Simms CL, et al. Dev Biol, 2010 May 15. PMID 20230814
    5. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Simmer F, et al. Curr Biol, 2002 Aug 6. PMID 12176360

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSH1 also able to hydrolyze xanthosine with high efficiency. NSH2 functions as a cytosolic, inosine-specific hydrolase induced by senescence. NSH3 encodes a purine hydrolase involved in extracellular nucleotide salvage.
      Title: Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines.
    2. Study identified a novel regulator of EGFR/RAS signaling, let-765/nsh-1, that functions upstream of the pathway to promote vulval induction; let-765 encodes a conserved DExD/H box helicase protein and is the ortholog of Drosophila strawberry notch.
      Title: A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans.
    3. Notch and Prospero repress proliferation following cyclin E overexpression in bristle cell lineage.
      Title: Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vulval cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vulval cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein strawberry notch homolog
    NP_498455.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6592525..6601173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066054.6 → NP_498455.2  Protein strawberry notch homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498455.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5LYH1, O01737
      Conserved Domains (2) summary
      pfam13871
      Location:1352 → 1630
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:632 → 936
      AAA_34; P-loop containing NTP hydrolase pore-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01737.3

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