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    cah-1 Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 186231, updated on 23-Nov-2023

    Summary

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    Gene symbol
    cah-1
    Gene description
    Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1
    Primary source
    WormBase:WBGene00000279
    Locus tag
    CELE_F54D8.4
    See related
    AllianceGenome:WB:WBGene00000279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in extracellular region. Is expressed in head ganglion; neurons; and ventral nerve cord. Orthologous to human CA10 (carbonic anhydrase 10) and CA11 (carbonic anhydrase 11). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See cah-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5083206..5085629, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cytochrome c oxidase subunit 6A, mitochondrial Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans. Sherman TA, et al. Biochim Biophys Acta, 2012 Apr. PMID 22245567, Free PMC Article
    2. Molecular and biochemical analysis of the α class carbonic anhydrases in Caenorhabditis elegans. Fasseas MK, et al. Mol Biol Rep, 2011 Mar. PMID 20842438
    3. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1
    NP_001309492.1
    • Partially confirmed by transcript evidence
    NP_001309597.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5083206..5085629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322586.2 → NP_001309492.1  Putative carbonic anhydrase-like protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20781
      Conserved Domains (1) summary
      cd03121
      Location:39 → 295
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    2. NM_001322587.1 → NP_001309597.1  Alpha-carbonic anhydrase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MB23
      Conserved Domains (1) summary
      cl00012
      Location:1 → 201
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein
    Heading Accession and Version

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