rab12 RAB12, member RAS oncogene family [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab12provided by ZNC
Official Full Name: RAB12, member RAS oncogene familyprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-555
See related: Ensembl:ENSDARG00000089428 AllianceGenome:ZFIN:ZDB-GENE-050522-555
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:111945
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; protein localization to plasma membrane; and secretion by cell. Predicted to act upstream of or within Rab protein signal transduction. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Is expressed in hindbrain; neural crest; and pharyngeal arch. Orthologous to human RAB12 (RAB12, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (54387710..54419031)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (54663063..54694384)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020630.1 → NP_001018466.1 ras-related protein Rab-12

See identical proteins and their annotated locations for NP_001018466.1

Status: PROVISIONAL

Source sequence(s)

BC095608

UniProtKB/TrEMBL

B2GS97, F6P1S2, Q502Q0

Related

ENSDARP00000110018.1, ENSDART00000127124.2

Conserved Domains (2) summary

smart00175
Location:36 → 200

RAB; Rab subfamily of small GTPases

cd04120
Location:36 → 235

Rab12; Rab GTPase family 12 (Rab12)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

54387710..54419031

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480399.1 → XP_021336074.1 ras-related protein Rab-12 isoform X1

UniProtKB/TrEMBL

A0A8M9QEU2

Conserved Domains (1) summary

cl21455
Location:13 → 160

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases