serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: serpind1provided by ZNC
Official Full Name: serpin peptidase inhibitor, clade D (heparin cofactor), member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030711-2
See related: Ensembl:ENSDARG00000021208 AllianceGenome:ZFIN:ZDB-GENE-030711-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: HCII
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within blood coagulation. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (1766170..1781733)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (1760965..1776527)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparin cofactor 2

Names: serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182880.1 → NP_878300.1 heparin cofactor 2 precursor

See identical proteins and their annotated locations for NP_878300.1

Status: PROVISIONAL

Source sequence(s)

AF515273

UniProtKB/TrEMBL

Q8AYE2

Related

ENSDARP00000073528.4, ENSDART00000079073.7

Conserved Domains (1) summary

cd02047
Location:61 → 505

HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

1766170..1781733

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166737.4 → XP_005166794.1 heparin cofactor 2 isoform X1

UniProtKB/TrEMBL

A0A8M2BE52, B0V3R7

Related

ENSDARP00000017995.7, ENSDART00000021820.9

Conserved Domains (1) summary

cd02047
Location:61 → 505

HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...