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    fbxo44.5 F-box protein 44, tandem duplicate 5 [ Danio rerio (zebrafish) ]

    Gene ID: 445148, updated on 27-Mar-2024

    Summary

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    Official Symbol
    fbxo44.5provided by ZNC
    Official Full Name
    F-box protein 44, tandem duplicate 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-53
    See related
    Ensembl:ENSDARG00000012035 AllianceGenome:ZFIN:ZDB-GENE-040801-53
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:100832
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; glycoprotein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See fbxo44.5 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (16815348..16822859)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (16888853..16896516)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438317 Neighboring gene F-box protein 6, tandem duplicate 2 Neighboring gene F-box protein 6, tandem duplicate 3 Neighboring gene uncharacterized LOC110438318 Neighboring gene F-box protein 44, tandem duplicate 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC445148

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003542.2 → NP_001003542.2  uncharacterized protein LOC445148 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL732515
      UniProtKB/TrEMBL
      A0A0R4I9Z2, A0A8M2B907, F1Q8M7, Q6DEK8
      Conserved Domains (2) summary
      pfam00646
      Location:1 → 46
      F-box; F-box domain
      pfam04300
      Location:67 → 241
      FBA; F-box associated region

    2. NM_001362483.1 → NP_001349412.1  uncharacterized protein LOC445148 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL732515
      UniProtKB/TrEMBL
      A0A0R4IQM2, A0A8M9P533, Q6DEK8
      Conserved Domains (2) summary
      pfam00646
      Location:30 → 75
      F-box; F-box domain
      pfam04300
      Location:96 → 270
      FBA; F-box associated region

    3. NM_001362484.1 → NP_001349413.1  uncharacterized protein LOC445148 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL732515
      UniProtKB/TrEMBL
      A0A0R4IQM2, A0A8M9P533, Q6DEK8
      Conserved Domains (2) summary
      pfam00646
      Location:30 → 75
      F-box; F-box domain
      pfam04300
      Location:96 → 270
      FBA; F-box associated region

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      16815348..16822859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469787.1 → XP_021325462.1  uncharacterized protein LOC445148 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IQM2, A0A8M9P533, Q6DEK8
      Conserved Domains (2) summary
      pfam00646
      Location:30 → 75
      F-box; F-box domain
      pfam04300
      Location:96 → 270
      FBA; F-box associated region

    2. XM_005162063.4 → XP_005162120.1  uncharacterized protein LOC445148 isoform X2

      UniProtKB/TrEMBL
      F1Q8M7
      Related
      ENSDARP00000118903.1, ENSDART00000143424.3
      Conserved Domains (2) summary
      pfam00646
      Location:1 → 46
      F-box; F-box domain
      pfam04300
      Location:67 → 241
      FBA; F-box associated region

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395360.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      270273..277758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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