mpx myeloid-specific peroxidase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mpxprovided by ZNC
Official Full Name: myeloid-specific peroxidaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9460
See related: Ensembl:ENSDARG00000019521 AllianceGenome:ZFIN:ZDB-GENE-030131-9460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: drf; mpo; fj80f04; wu:fj80f04
Summary: Enables peroxidase activity. Acts upstream of or within inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pleuroperitoneal region; and post-vent region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (7778870..7786020, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (7787705..7827254, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When infiltrated with Candida albicans, smu681 myeloperoxidase-deficient embryos and sibling embryos showed similar survival. Proliferation of C. albicans was more rapid in smu681 embryos than in sibling embryos, although it was eventually suppressed.
Title: Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans.
mpx expression is controlled differently in the anterior lateral plate mesoderm and posterior lateral plate mesoderm regions and describe novel roles for etv2 and gata1 during primitive neutropoiesis.
Title: Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish.
myeloperoxidase and H2O2 interact directly within neutrophils at the tissue wound
Title: Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj80f04.x1 (e-PCR)
- UniSTS:199967

AI496734 (e-PCR)
- UniSTS:206407

fb64b04 (e-PCR)
- UniSTS:189045

fi84c06.x1 (e-PCR)
- UniSTS:198095

fj79a06.y1 (e-PCR)
- UniSTS:199913

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eosinophil peroxidase

Names: myeloperoxidase; unm t30963; unm_sm681; unm_t30963

NP_001338766.1

EC 1.11.1.7

NP_997944.2

EC 1.11.1.7

XP_021334788.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001351837.1 → NP_001338766.1 eosinophil peroxidase isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CU681843

UniProtKB/TrEMBL

A0A8M1P4H4, Q90XS6

Related

ENSDARP00000043960.6, ENSDART00000043961.8

Conserved Domains (2) summary

pfam00386
Location:772 → 890

C1q; C1q domain

cl14561
Location:160 → 726

An_peroxidase_like; Animal heme peroxidases and related proteins
NM_212779.2 → NP_997944.2 eosinophil peroxidase isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CU681843

UniProtKB/TrEMBL

A0A8M1PIA8, F1Q944, Q90XS6

Related

ENSDARP00000103509.3, ENSDART00000111058.4

Conserved Domains (1) summary

cl14561
Location:160 → 726

An_peroxidase_like; Animal heme peroxidases and related proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

7778870..7786020 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479113.1 → XP_021334788.1 eosinophil peroxidase isoform X1

UniProtKB/TrEMBL

A0A8M9Q5S9, Q90XS6

Conserved Domains (2) summary

pfam00386
Location:771 → 889

C1q; C1q domain

cl14561
Location:159 → 725

An_peroxidase_like; Animal heme peroxidases and related proteins