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    meis2a Meis homeobox 2a [ Danio rerio (zebrafish) ]

    Gene ID: 170454, updated on 11-Apr-2024

    Summary

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    Official Symbol
    meis2aprovided by ZNC
    Official Full Name
    Meis homeobox 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020122-2
    See related
    Ensembl:ENSDARG00000098240 AllianceGenome:ZFIN:ZDB-GENE-020122-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa26d08; meis2.2; wu:fa26d08
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See meis2a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (52822091..52921306)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (52735916..52835155)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 98 member B Neighboring gene sprouty related EVH1 domain containing 1 Neighboring gene uncharacterized LOC110438055 Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene diphthamine biosynthesis 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogeny of the teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3b in the zebrafish. Santos JS, et al. Dev Dyn, 2010 Mar. PMID 20108322
    2. meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Bessa J, et al. Development, 2008 Mar. PMID 18216175
    3. Enhancers reside in a unique epigenetic environment during early zebrafish development. Kaaij LJ, et al. Genome Biol, 2016 Jul 5. PMID 27381023, Free PMC Article
    4. Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Dai YT, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35385357, Free PMC Article
    5. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Amin S, et al. Dev Cell, 2015 Feb 9. PMID 25640223, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis2; homeobox protein Meis2a
    Names
    myeloid ecotropic viral integration site 2.2
    myeloid ecotropic viral integration site 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131896.1 → NP_571971.1  homeobox protein Meis2a

      See identical proteins and their annotated locations for NP_571971.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056515
      UniProtKB/TrEMBL
      Q6PHK8
      Related
      ENSDARP00000155813.1, ENSDART00000193368.1
      Conserved Domains (2) summary
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      52822091..52921306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293342.3 → XP_009291617.1  homeobox protein Meis2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ARP6
      Conserved Domains (2) summary
      pfam05920
      Location:301 → 340
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_009293340.3 → XP_009291615.1  homeobox protein Meis2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AK57
      Conserved Domains (2) summary
      pfam05920
      Location:302 → 341
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_009293343.3 → XP_009291618.1  homeobox protein Meis2 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AJB0
      Conserved Domains (2) summary
      pfam05920
      Location:302 → 341
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. XM_009293344.3 → XP_009291619.1  homeobox protein Meis2 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B2P5
      Conserved Domains (2) summary
      pfam05920
      Location:289 → 328
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    5. XM_009293346.3 → XP_009291621.1  homeobox protein Meis2 isoform X7

      UniProtKB/TrEMBL
      A0A8M3AUM6
      Conserved Domains (2) summary
      pfam05920
      Location:289 → 328
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. XM_009293345.2 → XP_009291620.1  homeobox protein Meis2 isoform X6

      UniProtKB/TrEMBL
      A0A0H2UKR5, A0A8M3AK61
      Related
      ENSDARP00000137649.1, ENSDART00000161414.2
      Conserved Domains (2) summary
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:106 → 189
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. XM_009293341.3 → XP_009291616.1  homeobox protein Meis2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AUL9
      Related
      ENSDARP00000153019.1, ENSDART00000186979.1
      Conserved Domains (2) summary
      pfam05920
      Location:301 → 340
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:105 → 188
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein Strain
    Heading Accession and Version

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