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    aacs acetoacetyl-CoA synthetase [ Danio rerio (zebrafish) ]

    Gene ID: 393984, updated on 27-Mar-2024

    Summary

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    Official Symbol
    aacsprovided by ZNC
    Official Full Name
    acetoacetyl-CoA synthetaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-903
    See related
    Ensembl:ENSDARG00000012468 AllianceGenome:ZFIN:ZDB-GENE-040426-903
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56105
    Summary
    Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in liver; nervous system; neural tube; and optic vesicle. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See aacs in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (18822795..18897482, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (18319006..18393786, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-215k6.1 Neighboring gene uncharacterized LOC103911060 Neighboring gene bri3 binding protein Neighboring gene polymerase (DNA directed) iota

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate. Buerger AN, et al. Environ Pollut, 2019 Feb. PMID 30682743
    2. Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. Mirbahai L, et al. BMC Genomics, 2011 Jan 4. PMID 21205313, Free PMC Article
    3. Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Kopp R, et al. Physiol Genomics, 2010 Sep. PMID 20571107
    4. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC56105

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetoacetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetoacetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetoacetyl-CoA synthetase
    NP_957303.1
    XP_005165133.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201009.1 → NP_957303.1  acetoacetyl-CoA synthetase

      See identical proteins and their annotated locations for NP_957303.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050501
      UniProtKB/Swiss-Prot
      A3QK15
      Related
      ENSDARP00000090207.5, ENSDART00000099434.5
      Conserved Domains (2) summary
      cd05943
      Location:40 → 650
      AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)
      TIGR01217
      Location:16 → 658
      ac_ac_CoA_syn; acetoacetyl-CoA synthase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      18822795..18897482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165076.4 → XP_005165133.1  acetoacetyl-CoA synthetase isoform X1

      See identical proteins and their annotated locations for XP_005165133.1

      UniProtKB/Swiss-Prot
      A3QK15, Q7ZU87
      Related
      ENSDARP00000002180.8, ENSDART00000010101.10
      Conserved Domains (2) summary
      cd05943
      Location:40 → 664
      AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)
      TIGR01217
      Location:16 → 672
      ac_ac_CoA_syn; acetoacetyl-CoA synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3QK15.1 GenPept UniProtKB/Swiss-Prot:A3QK15

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