chfr checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chfrprovided by ZNC
Official Full Name: checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3522
See related: Ensembl:ENSDARG00000075347 AllianceGenome:ZFIN:ZDB-GENE-030131-3522
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc43f10; wu:fc43f10; si:dkey-69h6.7
Summary: Predicted to enable nucleotide binding activity and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cell division. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in central nervous system and presumptive diencephalon. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (17780447..17813303)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (17276411..17309303)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc43f10.x1 (e-PCR)
- UniSTS:188170

fj67f05.x1 (e-PCR)
- UniSTS:199831

fi11a09.y1 (e-PCR)
- UniSTS:196770

fi14h06.x1 (e-PCR)
- UniSTS:204468

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2/M transition checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase CHFR

Names: Checkpoint with forkhead and RING finger domains protein; RING-type E3 ubiquitin transferase CHFR

NP_001093485.1

EC 2.3.2.27

XP_017211627.1

EC 2.3.2.27

XP_017211628.1

EC 2.3.2.27

XP_021331941.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100015.1 → NP_001093485.1 E3 ubiquitin-protein ligase CHFR

See identical proteins and their annotated locations for NP_001093485.1

Status: PROVISIONAL

Source sequence(s)

CT573109

UniProtKB/Swiss-Prot

A5WW08, A8E4S5

UniProtKB/TrEMBL

A0A9U5BN82

Related

ENSDARP00000099431.3, ENSDART00000110783.5

Conserved Domains (2) summary

cd00060
Location:10 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00162
Location:276 → 319

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

17780447..17813303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356138.2 → XP_017211627.1 E3 ubiquitin-protein ligase CHFR isoform X1

UniProtKB/Swiss-Prot

A5WW08, A8E4S5

UniProtKB/TrEMBL

A0A9U5BN82

Conserved Domains (2) summary

cd00060
Location:10 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00162
Location:276 → 319

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_021476266.1 → XP_021331941.1 E3 ubiquitin-protein ligase CHFR isoform X2

UniProtKB/TrEMBL

A0A8M9Q8W8

Conserved Domains (2) summary

cd00060
Location:10 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd16503
Location:273 → 316

RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
XM_017356139.2 → XP_017211628.1 E3 ubiquitin-protein ligase CHFR isoform X2

UniProtKB/TrEMBL

A0A8M9Q8W8

Related

ENSDARP00000098332.2, ENSDART00000115227.2

Conserved Domains (2) summary

cd00060
Location:10 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd16503
Location:273 → 316

RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)