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    rfc5 replication factor C (activator 1) 5 [ Danio rerio (zebrafish) ]

    Gene ID: 445385, updated on 19-Jun-2024

    Summary

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    Official Symbol
    rfc5provided by ZNC
    Official Full Name
    replication factor C (activator 1) 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040907-1
    See related
    Ensembl:ENSDARG00000035634 AllianceGenome:ZFIN:ZDB-GENE-040907-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110313
    Summary
    Predicted to enable ATP binding activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Acts upstream of or within retina development in camera-type eye. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See rfc5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (12528734..12549746)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (12028517..12049529)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 1 (neuronal) Neighboring gene kinase suppressor of ras 2 Neighboring gene zgc:171242 Neighboring gene si:dkey-98f17.5 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene microRNA 22b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Heme regulates exocrine peptidase precursor genes in zebrafish. Wang H, et al. Exp Biol Med (Maywood), 2007 Oct. PMID 17895525
    2. Identification of zebrafish insertional mutants with defects in visual system development and function. Gross JM, et al. Genetics, 2005 May. PMID 15716491, Free PMC Article
    3. Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Kashyap B, et al. Reprod Toxicol, 2014 Jan. PMID 24355176, Free PMC Article
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 5
    Names
    replication factor C subunit RFC5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003862.1 → NP_001003862.1  replication factor C subunit 5

      See identical proteins and their annotated locations for NP_001003862.1

      Status: PROVISIONAL

      Source sequence(s)
      AY648755
      UniProtKB/TrEMBL
      A0A8M1N1T8, Q6DRK4
      Related
      ENSDARP00000051669.4, ENSDART00000051670.5
      Conserved Domains (4) summary
      cd00009
      Location:29 → 170
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK00440
      Location:12 → 323
      rfc; replication factor C small subunit; Reviewed
      pfam08542
      Location:252 → 321
      Rep_fac_C; Replication factor C C-terminal domain
      pfam16193
      Location:186 → 214
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      12528734..12549746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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