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    nectin3b nectin cell adhesion molecule 3b [ Danio rerio (zebrafish) ]

    Gene ID: 541491, updated on 27-Mar-2024

    Summary

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    Official Symbol
    nectin3bprovided by ZNC
    Official Full Name
    nectin cell adhesion molecule 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-14
    See related
    Ensembl:ENSDARG00000006604 AllianceGenome:ZFIN:ZDB-GENE-050327-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pvrl3b; pvrl3l; fj99c02; nectin3; wu:fj99c02; zgc:113035
    Summary
    Predicted to enable cell adhesion molecule binding activity and protein homodimerization activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion and spermatid development. Predicted to be located in cell-cell junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in adherens junction and apical junction complex. Orthologous to human NECTIN3 (nectin cell adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See nectin3b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (21450454..21515466, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (21413818..21478830, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) Neighboring gene reticulon 2b Neighboring gene diablo, IAP-binding mitochondrial protein b Neighboring gene odorant receptor, family A, subfamily 113, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Ferrante MI, et al. Hum Mol Genet, 2009 Jan 15. PMID 18971206, Free PMC Article
    2. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
    3. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nectin-3-like protein
    Names
    nectin cell adhesion molecule 3
    poliovirus receptor-related 3 like
    poliovirus receptor-related 3b
    poliovirus receptor-related protein 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014304.1 → NP_001014326.1  nectin-3-like protein precursor

      See identical proteins and their annotated locations for NP_001014326.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091923
      UniProtKB/Swiss-Prot
      A4JYI1, A4JYN6, Q58EG3
      UniProtKB/TrEMBL
      B2GPN6
      Related
      ENSDARP00000121706.1, ENSDART00000147593.3
      Conserved Domains (4) summary
      cd05887
      Location:51 → 148
      Ig1_Nectin-3_like; First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
      cd07704
      Location:151 → 247
      Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
      smart00408
      Location:267 → 327
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:42 → 147
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      21450454..21515466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58EG3.2 GenPept UniProtKB/Swiss-Prot:Q58EG3

    Gene LinkOut

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