MGM1 dynamin-related GTPase MGM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MGM1
Gene description: dynamin-related GTPase MGM1
Primary source: FungiDB:YOR211C
Locus tag: YOR211C
See related: SGD:S000005737; AllianceGenome:SGD:S000005737; VEuPathDB:YOR211C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MNA1
Summary: Enables GTPase activity and phospholipid binding activity. Involved in heme transport; membrane fusion; and mitochondrion organization. Located in mitochondrial envelope. Is extrinsic component of mitochondrial inner membrane and intrinsic component of mitochondrial inner membrane. Used to study Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; and optic atrophy 1. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MGM1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (738924..741569, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A double deletion mutant in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated are characterized by impaired respiration and a decrease in mitophagy and replicative lifespan
Title: Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan.
Mgm1 membrane interactions impose a mechanical force on the membrane to overcome the hydrophilic repulsion of the phospholipid head groups and initiate the fusion reaction.
Title: Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending.
Psd1 promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of Mgm1.
Title: Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1).
Mechanistic details of the two known in vivo functions of Mgm1, membrane fusion and cristae maintenance.
Title: Membrane tethering and nucleotide-dependent conformational changes drive mitochondrial genome maintenance (Mgm1) protein-mediated membrane fusion.
Absence of mitochondrial fusion in the Deltamgm1 mutant leads to a striking reduction of both replicative and chronological lifespan.
Title: Unopposed mitochondrial fission leads to severe lifespan shortening.
Data show that charged residues in the regions flanking the first segment in Mgm1p critically affect the ratio between the two isoforms, providing new insight of charged residues in the insertion of proteins into the mitochondrial inner membrane.
Title: Charged flanking residues control the efficiency of membrane insertion of the first transmembrane segment in yeast mitochondrial Mgm1p.
transmembrane segments of inner membrane proteins that are normally not processed by Pcp1 become cleavable when put in place of the authentic 'rhomboid cleavage region' (RCR) of Mgm1
Title: Intramembrane proteolysis of Mgm1 by the mitochondrial rhomboid protease is highly promiscuous regarding the sequence of the cleaved hydrophobic segment.
Mgm1 promotes the fusion of opposing mitochondrial inner membranes
Title: Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion.
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion.
Title: Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion.
Trans Mgm1 interactions on opposing inner membranes function similarly to tether and fuse inner membranes as well as maintain crista structures and propose a model for how the mitochondrial dynamins function to facilitate fusion.
Title: Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables cardiolipin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cristae formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner boundary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner boundary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynamin-related GTPase MGM1

NP_014854.2

Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; plays a direct role in formation and maintenance of lamellar, but not of tubular, cristae; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

738924..741569 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183630.1 → NP_014854.2 TPA: dynamin-related GTPase MGM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014854.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2R7, P32266, Q02609, Q08627

UniProtKB/TrEMBL

A0A8H4FAD9, C7GWH1

Conserved Domains (2) summary

cd08771
Location:208 → 468

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:93 → 826

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]