slc3a2a solute carrier family 3 member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc3a2aprovided by ZNC
Official Full Name: solute carrier family 3 member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000831-3
See related: Ensembl:ENSDARG00000036427 AllianceGenome:ZFIN:ZDB-GENE-000831-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slc3a2; fc65h12; wu:fc65h12
Summary: Predicted to enable catalytic activity. Acts upstream of or within regulation of syncytium formation by plasma membrane fusion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in nervous system; notochord; pancreas primordium; solid lens vesicle; and yolk syncytial layer. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (20524068..20530447)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (20272100..20278479)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc3a2 inhibits the RhoA/ROCK pathway via phosphorylation of c-Src to modulate YSL microtubule dynamics.
Title: Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo.

Submit: New GeneRIF Correction

General gene information

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Markers

fc42f01.y1 (e-PCR)
- UniSTS:193824

fc65h12.x1 (e-PCR)
- UniSTS:203983

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-leucine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phenylalanine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of syncytium formation by plasma membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 3 member 2a

Names: solute carrier family 3 (amino acid transporter heavy chain), member 2a; solute carrier family 3, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131601.2 → NP_571676.2 solute carrier family 3 member 2a

Status: VALIDATED

Source sequence(s)

CR318653

UniProtKB/TrEMBL

A0A8M1PBP2, F1QSI9

Related

ENSDARP00000052916.6, ENSDART00000052917.8

Conserved Domains (3) summary

cd11345
Location:94 → 396

AmyAc_SLC3A2; Alpha amylase catalytic domain found in solute carrier family 3 member 2 proteins

COG0366
Location:125 → 445

AmyA; Glycosidase [Carbohydrate transport and metabolism]

pfam16028
Location:42 → 111

SLC3A2_N; Solute carrier family 3 member 2 N-terminus