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    lapB lipopolysaccharide assembly protein B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944858, updated on 2-May-2024

    Summary

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    Gene symbol
    lapB
    Gene description
    lipopolysaccharide assembly protein B
    Primary source
    ASAP:ABE-0004300
    Locus tag
    b1280
    See related
    ECOCYC:EG12691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1275; yciM
    Summary
    YciM has six tandem TPR repeats that are usually involved in protein-protein interactions. [More information is available at EcoGene: EG12691].
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    Genomic context

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    Sequence:
    NC_000913.3 (1340558..1341727)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphatidylglycerophosphatase B Neighboring gene lipopolysaccharide assembly protein A Neighboring gene orotidine-5'-phosphate decarboxylase Neighboring gene putative translation factor Neighboring gene osmotically-inducible lipoprotein OsmB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli. Mahalakshmi S, et al. Mol Microbiol, 2014 Jan. PMID 24266962
    2. Insights into the function of YciM, a heat shock membrane protein required to maintain envelope integrity in Escherichia coli. Nicolaes V, et al. J Bacteriol, 2014 Jan. PMID 24187084, Free PMC Article
    3. An Unexpected Duo: Rubredoxin Binds Nine TPR Motifs to Form LapB, an Essential Regulator of Lipopolysaccharide Synthesis. Prince C, et al. Structure, 2015 Aug 4. PMID 26190574
    4. A consensus sequence of three DNA replication terminus sites on the E. coli chromosome is highly homologous to the terR sites of the R6K plasmid. Hidaka M, et al. Cell, 1988 Nov 4. PMID 3052852
    5. The inner membrane protein LapB is required for adaptation to cold stress in an LpxC-independent manner. Lee HB, et al. J Microbiol, 2021 Jul. PMID 33990910

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The inner membrane protein LapB is required for adaptation to cold stress in an LpxC-independent manner.
      Title: The inner membrane protein LapB is required for adaptation to cold stress in an LpxC-independent manner.
    2. YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide.
      Title: YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide.
    3. Rubredoxin binds nine TPR motifs to form LapB, an essential regulator of lipopolysaccharide synthesis.
      Title: An Unexpected Duo: Rubredoxin Binds Nine TPR Motifs to Form LapB, an Essential Regulator of Lipopolysaccharide Synthesis.
    4. Study demonstrates an essential role for YciM in regulation of lipopolysaccharide biosynthesis in E. coli.
      Title: yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli.
    5. Results indicate that YciM is required for envelope integrity.
      Title: Insights into the function of YciM, a heat shock membrane protein required to maintain envelope integrity in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipopolysaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipopolysaccharide assembly protein B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1340558..1341727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415796.1 lipopolysaccharide assembly protein B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415796.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PDH2, A0A3T9RTI1
      Conserved Domains (2) summary
      COG2956
      Location:10 → 388
      YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]
      sd00006
      Location:180 → 208
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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