ROMO1 reactive oxygen species modulator 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ROMO1provided by HGNC
Official Full Name: reactive oxygen species modulator 1provided by HGNC
Primary source: HGNC:HGNC:16185
See related: Ensembl:ENSG00000125995 MIM:618894; AllianceGenome:HGNC:16185
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTGM; MTGMP; C20orf52; bA353C18.2
Summary: The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]
Expression: Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (35699405..35700980)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (37420181..37421955)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (34287327..34288902)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of ROMO1 on cervical cancer progression.
Title: The effects of ROMO1 on cervical cancer progression.
Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
Title: Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker.
Title: Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker.
Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.
Title: Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.
The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus.
Title: The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus.
Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
Title: Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
Title: Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer.
Title: Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer.
Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
Title: Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
serum Romo1 levels increase in COPD patients and these levels are associated with lung function, inflammation, and oxidative stress in COPD.
Title: Increased Serum Romo1 Was Correlated with Lung Function, Inflammation, and Oxidative Stress in Chronic Obstructive Pulmonary Disease.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD05448 (e-PCR)
- UniSTS:286514

ECD00802 (e-PCR)
- UniSTS:281911

REN58757 (e-PCR)
- UniSTS:383557

REN58758 (e-PCR)
- UniSTS:383558

REN58759 (e-PCR)
- UniSTS:383559

REN58760 (e-PCR)
- UniSTS:383560

REN58761 (e-PCR)
- UniSTS:383561

REN58762 (e-PCR)
- UniSTS:383562

REN58763 (e-PCR)
- UniSTS:383563

REN58764 (e-PCR)
- UniSTS:383564

REN58765 (e-PCR)
- UniSTS:383565

REN58766 (e-PCR)
- UniSTS:383566

REN58767 (e-PCR)
- UniSTS:383567

REN58768 (e-PCR)
- UniSTS:383568

REN58769 (e-PCR)
- UniSTS:383569

REN58770 (e-PCR)
- UniSTS:383570

REN58771 (e-PCR)
- UniSTS:383571

REN58772 (e-PCR)
- UniSTS:383572

REN58773 (e-PCR)
- UniSTS:383573

ECD11665 (e-PCR)
- UniSTS:292701

RH41786 (e-PCR)
- UniSTS:14767

STS-D45601 (e-PCR)
- UniSTS:28155

ECD12340 (e-PCR)
- UniSTS:293373

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables monoatomic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytolysis by host of symbiont cells	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in killing of cells of another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in killing of cells of another organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replicative senescence	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
part_of TIM23 mitochondrial import inner membrane translocase complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: reactive oxygen species modulator 1

Names: PCM19; ROS modulator 1; epididymis tissue protein Li 175; glyrichin; mitochondrial targeting GXXXG protein; mitochondrial targeting GxxxG motif protein; protein MGR2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080748.3 → NP_542786.1 reactive oxygen species modulator 1

See identical proteins and their annotated locations for NP_542786.1

Status: REVIEWED

Source sequence(s)

AK000548, BC105281

Consensus CDS

CCDS13264.1

UniProtKB/Swiss-Prot

A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2

Related

ENSP00000363190.3, ENST00000374077.8

Conserved Domains (1) summary

pfam10247
Location:14 → 79

Romo1; Reactive mitochondrial oxygen species modulator 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

35699405..35700980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017027678.2 → XP_016883167.1 reactive oxygen species modulator 1 isoform X1

UniProtKB/Swiss-Prot

A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2

Related

ENSP00000363191.1, ENST00000374078.5

Conserved Domains (1) summary

pfam10247
Location:14 → 79

Romo1; Reactive mitochondrial oxygen species modulator 1