Cand2 cullin associated and neddylation dissociated 2 (putative) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cand2provided by MGI
Official Full Name: cullin associated and neddylation dissociated 2 (putative)provided by MGI
Primary source: MGI:MGI:1914338
See related: Ensembl:ENSMUSG00000030319 AllianceGenome:MGI:1914338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tp120b; mKIAA0667; 2210404G23Rik
Summary: Enables TBP-class protein binding activity. Predicted to be involved in SCF complex assembly and protein ubiquitination. Located in nucleus. Is expressed in several structures, including limb bud; musculature; and nervous system. Orthologous to human CAND2 (cullin associated and neddylation dissociated 2 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 24.2), heart adult (RPKM 22.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 53.71 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (115751518..115782516)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (115774557..115805555)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAND2 inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation
Title: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235528

RH135165 (e-PCR)
- UniSTS:218442

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cullin-associated NEDD8-dissociated protein 2

Names: TBP-interacting protein 120B; TBP-interacting protein b; TBP-interacting protein of 120 kDa B; cullin-associated and neddylation-dissociated protein 2; p120 CAND2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025958.2 → NP_080234.2 cullin-associated NEDD8-dissociated protein 2

See identical proteins and their annotated locations for NP_080234.2

Status: VALIDATED

Source sequence(s)

BC056365, BC058338, BP761509, BY553771, CJ299742

Consensus CDS

CCDS20442.1

UniProtKB/Swiss-Prot

Q6PHT7, Q6ZQ73

UniProtKB/TrEMBL

Q3UM57

Related

ENSMUSP00000075377.6, ENSMUST00000075995.7

Conserved Domains (3) summary

pfam08623
Location:1057 → 1206

TIP120; TATA-binding protein interacting (TIP20)

pfam13513
Location:150 → 202

HEAT_EZ; HEAT-like repeat

sd00044
Location:864 → 886

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

115751518..115782516

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255552.2 → XP_030111412.1 cullin-associated NEDD8-dissociated protein 2 isoform X1

Conserved Domains (4) summary

COG1413
Location:392 → 558

HEAT; HEAT repeat [General function prediction only]

sd00044
Location:391 → 413

HEAT; HEAT repeat [structural motif]

pfam08623
Location:584 → 733

TIP120; TATA-binding protein interacting (TIP20)

pfam13513
Location:367 → 414

HEAT_EZ; HEAT-like repeat