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    Adam22 ADAM metallopeptidase domain 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57033, updated on 6-Jun-2024

    Summary

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    Symbol
    Adam22provided by RGD
    Full Name
    ADAM metallopeptidase domain 22provided by RGD
    Primary source
    RGD:1585016
    See related
    Ensembl:ENSRNOG00000042478 AllianceGenome:RGD:1585016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MDC2
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to act upstream of or within adult locomotory behavior and myelination in peripheral nervous system. Predicted to be located in axon and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 418.8), Kidney (RPKM 61.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adam22 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26670984..26925843)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25716055..25970932)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22864485..23002969)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3B Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene transfer RNA proline (anticodon AGG) 72 Neighboring gene uncharacterized LOC120102223 Neighboring gene sorcin Neighboring gene uncharacterized LOC134486721 Neighboring gene STEAP4 metalloreductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Disintegrin and Metalloprotease-22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway. Ren L, et al. J Am Heart Assoc, 2018 Jan 22. PMID 29358191, Free PMC Article
    2. Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. VanGuilder Starkey HD, et al. Cell Mol Neurobiol, 2013 May. PMID 23525710, Free PMC Article
    3. ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. Hivert B, et al. J Cell Sci, 2019 Jan 16. PMID 30598502
    4. Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. Sagane K, et al. BMC Neurosci, 2005 May 6. PMID 15876356, Free PMC Article
    5. Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy. Muona M, et al. Neurol Genet, 2016 Feb. PMID 27066583, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A disintegrin and metalloproteinase 22 activates integrin beta1 through its disintegrin domain to promote the progression of pituitary adenoma.
      Title: A disintegrin and metalloproteinase 22 activates integrin β1 through its disintegrin domain to promote the progression of pituitary adenoma.
    2. ADAM22 and ADAM23 also associate with Caspr2 and TAG-1 (also known as CNTN2) to be selectively targeted to different axonal sub-regions. Hence, the combinatorial expression of Kv1-associated CAMs may be critical to tune intrinsic excitability in physiological and epileptogenic contexts.
      Title: ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.
    3. ADAM22 negatively regulates cardiac myocyte AKT activation and the process of cardiac hypertrophy.
      Title: A Disintegrin and Metalloprotease-22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway.
    4. The expression of LOTUS, LGI1, and ADAM22 in hippocampal subregions dissected from mature adult and aged rats cognitively phenotyped for spatial learning and memory by Morris water maze testing, was quantified.
      Title: Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
    5. ADAM22, a transmembrane protein that when mutated causes seizure, serves as a receptor for LGI1; mutated form of LGI1 fails to bind to ADAM22
      Title: Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gliogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloprotease domain (ADAM) 22
    a disintegrin and metalloprotease domain 22
    disintegrin and metalloproteinase domain-containing protein 22-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427457.1 → NP_001414386.1  disintegrin and metalloproteinase domain-containing protein 22 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6G7Y5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26670984..26925843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286647.1 → XP_063142717.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

      UniProtKB/TrEMBL
      A0A8I6G6D0

    2. XM_039108561.1 → XP_038964489.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G7Y5
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_039108564.1 → XP_038964492.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6E8, A0A8I6G7Y5
      Related
      ENSRNOP00000077847.1, ENSRNOT00000099765.1
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_039108563.1 → XP_038964491.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G7Y5
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    5. XM_039108565.2 → XP_038964493.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G7Y5
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    6. XM_039108567.2 → XP_038964495.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G6D0
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    7. XM_063286643.1 → XP_063142713.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G6D0

    8. XM_039108569.2 → XP_038964497.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

      UniProtKB/TrEMBL
      A0A8I6G6D0
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    9. XM_063286645.1 → XP_063142715.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      UniProtKB/TrEMBL
      A0A8I6G6D0, A0A8I6GKI4

    10. XM_039108568.2 → XP_038964496.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMW2, A0A8I6G7Y5
      Related
      ENSRNOP00000094323.1
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    11. XM_063286644.1 → XP_063142714.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G7Y5

    12. XM_039108571.2 → XP_038964499.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      UniProtKB/TrEMBL
      A0A8I6G6D0, F1M542
      Related
      ENSRNOP00000059289.4
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    13. XM_039108572.2 → XP_038964500.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      UniProtKB/TrEMBL
      A0A8I6G6D0
      Conserved Domains (4) summary
      smart00050
      Location:450 → 525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527 → 668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236 → 435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    14. XM_063286646.1 → XP_063142716.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    RNA

    1. XR_010065701.1 RNA Sequence

    2. XR_005503424.2 RNA Sequence

    3. XR_010065699.1 RNA Sequence

    4. XR_010065700.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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