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    GNG7 G protein subunit gamma 7 [ Homo sapiens (human) ]

    Gene ID: 2788, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GNG7provided by HGNC
    Official Full Name
    G protein subunit gamma 7provided by HGNC
    Primary source
    HGNC:HGNC:4410
    See related
    Ensembl:ENSG00000176533 MIM:604430; AllianceGenome:HGNC:4410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG3B
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 18.8), heart (RPKM 10.5) and 22 other tissues See more
    Orthologs
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    Genomic context

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    See GNG7 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2511219..2702694, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2487421..2678899, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2511217..2702692, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2494323-2495030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2511755-2512265 Neighboring gene uncharacterized LOC124904789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13697 Neighboring gene RNA, U6 small nuclear 993, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2518390-2519062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13698 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2540747-2541566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2541567-2542386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2543207-2544026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2544027-2544846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2544847-2545665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2546759-2547703 Neighboring gene elongin C pseudogene 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2556671-2557284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2559714-2560214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2567191-2567718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2567719-2568246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2575316-2575816 Neighboring gene HNF4 motif-containing MPRA enhancer 50 Neighboring gene Sharpr-MPRA regulatory region 4130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2587299-2588242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2592455-2592956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2603289-2604055 Neighboring gene RNA, 7SL, cytoplasmic 121, pseudogene Neighboring gene H3K4me1 hESC enhancers GRCh37_chr19:2607315-2608169 and GRCh37_chr19:2608170-2609023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9803 Neighboring gene Sharpr-MPRA regulatory region 3019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13710 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:2626979-2628178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2643435-2643934 Neighboring gene microRNA 7850 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2650512-2650687 Neighboring gene GNG7 intron CAGE-defined B cell enhancer Neighboring gene MPRA-validated peak3237 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2678080-2678228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2723575-2724487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2734868-2735368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2735369-2735869 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2739111-2739378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9805 Neighboring gene DIRAS family GTPase 1 Neighboring gene solute carrier family 39 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments. Duan H, et al. Aging (Albany NY), 2023 Feb 24. PMID 36863706, Free PMC Article
    2. G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1. Zheng H, et al. Int J Biol Macromol, 2021 Jul 1. PMID 33864871
    3. G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma. Xu S, et al. J Cell Physiol, 2019 Nov. PMID 30945310, Free PMC Article
    4. Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling. Demokan S, et al. Int J Oncol, 2013 Apr. PMID 23403885, Free PMC Article
    5. Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck. Hartmann S, et al. J Appl Genet, 2012 May. PMID 22183866, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments.
      Title: Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments.
    2. Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis.
      Title: Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis.
    3. MicroRNA miR-19b-3p mediated G protein gamma subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.
      Title: MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.
    4. GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.
      Title: GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.
    5. G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.
      Title: G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.
    6. Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia.
      Title: Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia.
    7. GNG7 is a tumor suppressor gene in Clear cell renal cell carcinoma progression.
      Title: G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma.
    8. GNG7 is a highly specific promoter methylated gene associated with head and neck cancer.
      Title: Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling.
    9. Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation.
      Title: Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.
    10. Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC.
      Title: Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00058

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Names
    guanine nucleotide binding protein (G protein), gamma 7
    heterotrimeric guanine nucleotide-binding protein 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052847.3 → NP_443079.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

      See identical proteins and their annotated locations for NP_443079.1

      Status: VALIDATED

      Source sequence(s)
      AC005512, BC014466, BC053630, DA247608
      Consensus CDS
      CCDS12091.1
      UniProtKB/Swiss-Prot
      B2R496, O60262
      Related
      ENSP00000371594.2, ENST00000382159.8
      Conserved Domains (1) summary
      smart00224
      Location:7 → 68
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      2511219..2702694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438629.1 → XP_047294585.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      B2R496, O60262

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      2487421..2678899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320580.1 → XP_054176555.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      B2R496, O60262

    2. XM_054320581.1 → XP_054176556.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      B2R496, O60262
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60262.1 GenPept UniProtKB/Swiss-Prot:O60262

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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