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    CG5846 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34326, updated on 10-May-2024

    Summary

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    Official Symbol
    CG5846provided by FlyBase
    Primary source
    FLYBASE:FBgn0032171
    Locus tag
    Dmel_CG5846
    See related
    AllianceGenome:FB:FBgn0032171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5846
    Summary
    Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to several human genes including RFXANK (regulatory factor X associated ankyrin containing protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG5846 in Genome Data Viewer
    Location:
    30F2-30F2; 2-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9956175..9957237, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9956175..9957019, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45949 Neighboring gene mir-87 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44872 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila. Marcogliese PC, et al. Hum Mol Genet, 2017 Apr 1. PMID 28158614, Free PMC Article
    2. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860
    3. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article
    4. Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9. Schwartz S, et al. Genetics, 2016 Jul. PMID 27182943, Free PMC Article
    5. A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1. Kavi H, et al. G3 (Bethesda), 2015 Jan 27. PMID 25628309, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5846-PA
    CG5846-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9956175..9957237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135489.4 → NP_609333.1  uncharacterized protein Dmel_CG5846, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL58
      Related
      FBpp0079487
      Conserved Domains (3) summary
      cd00204
      Location:94 → 218
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:104 → 196
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:99 → 130
      ANK; ANK repeat [structural motif]

    2. NM_001316389.1 → NP_001303318.1  uncharacterized protein Dmel_CG5846, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL58
      Conserved Domains (3) summary
      cd00204
      Location:94 → 218
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:104 → 196
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:99 → 130
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL58 Q9VL58

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