Lrrc26 leucine rich repeat containing 26 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc26provided by RGD
Official Full Name: leucine rich repeat containing 26provided by RGD
Primary source: RGD:1308398
See related: Ensembl:ENSRNOG00000011457 AllianceGenome:RGD:1308398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308398
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC26 (leucine rich repeat containing 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 8.3), Lung (RPKM 3.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28500517..28501843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8102361..8103687)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2506426..2507752)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study indicates that arterial myocytes express LRRC26 which functions as BK channel gamma subunit.
Title: LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 26

Names: BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014053.1 → NP_001014075.1 leucine-rich repeat-containing protein 26 precursor

See identical proteins and their annotated locations for NP_001014075.1

Status: VALIDATED

Source sequence(s)

BC061729

UniProtKB/Swiss-Prot

Q6P7C4

UniProtKB/TrEMBL

A6JT32

Related

ENSRNOP00000015242.2, ENSRNOT00000015242.4

Conserved Domains (4) summary

sd00033
Location:77 → 100

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:125 → 164

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:76 → 135

LRR_8; Leucine rich repeat

cl15307
Location:205 → 258

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain