Crb3 crumbs cell polarity complex component 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crb3provided by RGD
Official Full Name: crumbs cell polarity complex component 3provided by RGD
Primary source: RGD:1565035
See related: Ensembl:ENSRNOG00000070099 AllianceGenome:RGD:1565035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity. Predicted to be involved in positive regulation of cell junction assembly and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human CRB3 (crumbs cell polarity complex component 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 92.1), Lung (RPKM 49.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1985504..1990855)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (1898531..1903860)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (9982529..9986896, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRB3 is an actin microfilament regulator, playing a pivotal role in organizing actin filament bundles at the ectoplasmic specialization.
Title: Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AU015179 (e-PCR)
- UniSTS:160676

RH131689 (e-PCR)
- UniSTS:214972

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of subapical complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein crumbs homolog 3

Names: crumbs 3, cell polarity complex component; crumbs family member 3; crumbs homolog 3; crumbs protein homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.