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    dpr6 defective proboscis extension response 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50296, updated on 10-May-2024

    Summary

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    Official Symbol
    dpr6provided by FlyBase
    Official Full Name
    defective proboscis extension response 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0040823
    Locus tag
    Dmel_CG14162
    See related
    AllianceGenome:FB:FBgn0040823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD13525; CG14162; Dmel\CG14162; Dpr-6; Dpr6
    Summary
    Involved in synapse organization. Located in neuron projection membrane. Is expressed in larval ventral nerve cord; medulla; and organism. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See dpr6 in Genome Data Viewer
    Location:
    67D2-67D8; 3-32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9974651..10139360)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9967751..10132460)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45876 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45877 Neighboring gene variable nurse cells Neighboring gene long non-coding RNA:CR45155 Neighboring gene long non-coding RNA:CR45878 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sting-regulated gene 2 Neighboring gene pseudo Neighboring gene defective proboscis extension response 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exercise-induced changes in climbing performance. Watanabe LP, et al. R Soc Open Sci, 2021 Nov. PMID 34804578, Free PMC Article
    2. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
    3. Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules. Xu S, et al. Cell Rep, 2022 Apr 5. PMID 35385751, Free PMC Article
    4. Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits. Xu S, et al. Neuron, 2018 Dec 19. PMID 30467079, Free PMC Article
    5. Coordination between stochastic and deterministic specification in the Drosophila visual system. Courgeon M, et al. Science, 2019 Oct 18. PMID 31582524, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
      Title: Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective proboscis extension response 6
    Names
    CG14162-PA
    CG14162-PC
    CG14162-PD
    CG14162-PE
    CG14162-PF
    defective proboscis response 6
    dpr6-PA
    dpr6-PC
    dpr6-PD
    dpr6-PE
    dpr6-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9974651..10139360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274746.1 → NP_001261675.1  defective proboscis extension response 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF70
      Conserved Domains (3) summary
      smart00408
      Location:191 → 262
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:184 → 271
      IG_like; Immunoglobulin like
      pfam07686
      Location:79 → 174
      V-set; Immunoglobulin V-set domain

    2. NM_001274745.1 → NP_001261674.1  defective proboscis extension response 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PES4
      Conserved Domains (3) summary
      smart00408
      Location:191 → 262
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:184 → 271
      IG_like; Immunoglobulin like
      pfam07686
      Location:79 → 174
      V-set; Immunoglobulin V-set domain

    3. NM_001300089.2 → NP_001287018.1  defective proboscis extension response 6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8X8
      Conserved Domains (3) summary
      smart00408
      Location:191 → 262
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:184 → 271
      IG_like; Immunoglobulin like
      pfam07686
      Location:79 → 174
      V-set; Immunoglobulin V-set domain

    4. NM_001274744.2 → NP_001261673.1  defective proboscis extension response 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC40
      Conserved Domains (3) summary
      smart00408
      Location:191 → 262
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:184 → 271
      IG_like; Immunoglobulin like
      cl11960
      Location:79 → 174
      Ig; Immunoglobulin domain

    5. NM_144182.2 → NP_652439.1  defective proboscis extension response 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0B9, Q9VT76
      Related
      FBpp0076082
      Conserved Domains (3) summary
      smart00408
      Location:191 → 262
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:184 → 271
      IG_like; Immunoglobulin like
      pfam07686
      Location:79 → 174
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC40 M9PC40
    M9PES4 M9PES4
    M9PF70 M9PF70
    Q9VT76 Q9VT76
    X2J8X8 X2J8X8

    Gene LinkOut

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